Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds
文献类型：期刊论文
| 作者 | Wang, Shi-Zhi9,10; Yan, Yu8; Widlund, Malin7; Qian, Chen-Chang6,10; Zhang, Liang-Liang5; Zhang, Shao-Jie6,10; Li, Zi-Mai4; Cao, Peng3; Dai, Qing-Yan3; Feng, Xiao-Tian3 |
| 刊名 | MOLECULAR BIOLOGY AND EVOLUTION
 |
| 出版日期 | 2024-07-05 |
| 卷号 | 41期号:7页码:12 |
| 关键词 | historic dog fur lapphund elkhound genetic origin artificial selection population genomics |
| ISSN号 | 0737-4038 |
| DOI | 10.1093/molbev/msae108 |
| 英文摘要 | The origins and extreme morphological evolution of the modern dog breeds are poorly studied because the founder populations are extinct. Here, we analyse eight 100 to 200 years old dog fur samples obtained from traditional North Swedish clothing, to explore the origin and artificial selection of the modern Nordic Lapphund and Elkhound dog breeds. Population genomic analysis confirmed the Lapphund and Elkhound breeds to originate from the local dog population, and showed a distinct decrease in genetic diversity in agreement with intense breeding. We identified eleven genes under positive selection during the breed development. In particular, the MSRB3 gene, associated with breed-related ear morphology, was selected in all Lapphund and Elkhound breeds, and functional assays showed that a SNP mutation in the 3 ' UTR region suppresses its expression through miRNA regulation. Our findings demonstrate analysis of near-modern dog artifacts as an effective tool for interpreting the origin and artificial selection of the modern dog breeds. |
| WOS关键词 | GENOME SEQUENCE ; VILLAGE DOGS ; DIVERSITY ; SUGGESTS ; REVEALS ; TOOL |
| 资助项目 | NSFC[32170436] ; NSFC[32360122] ; National Key R&D Program of China[2019YFA0707101] ; Agria och SKK Forskningsfond for sallskapsdjur[N2021-0019] ; Agria och SKK Forskningsfond for sallskapsdjur[2021ZD0203900] ; Spring City Plan: the High-level Talent Promotion and Training Project of Kunming[2022SCP001] ; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences[GREKF21-10] ; Yunnan Fundamental Research Projects[202201AV070011] ; Aatos Erkko Foundation ; HiLIFE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:001262905200002 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://119.78.100.205/handle/311034/23816]  |
| 专题 | 中国科学院古脊椎动物与古人类研究所 |
| 通讯作者 | Savolainen, Peter; Wang, Guo-Dong |
| 作者单位 | 1.Folkhalsan Res Ctr, Helsinki, Finland 2.Univ Helsinki, Dept Med & Clin Genet, Dept Vet Biosci, Helsinki, Finland 3.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing, Peoples R China 4.Shandong Univ, State Key Lab Microbial Technol, Qingdao, Peoples R China 5.Zhejiang Normal Univ, Xingzhi Coll, Jinhua, Peoples R China 6.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Peoples R China 7.KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Stockholm, Sweden 8.Yunnan Univ, State Key Lab Conservat & Utilizat Bioresources Yu, Kunming, Peoples R China 9.Yunnan Anim Sci & Vet Inst, Kunming, Peoples R China 10.Chinese Acad Sci, Kunming Inst Zool, Key Lab Genet Evolut & Anim Models, Yunnan Key Lab Mol Biol Domest Anim, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Shi-Zhi,Yan, Yu,Widlund, Malin,et al. Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds[J]. MOLECULAR BIOLOGY AND EVOLUTION,2024,41(7):12. |
| APA | Wang, Shi-Zhi.,Yan, Yu.,Widlund, Malin.,Qian, Chen-Chang.,Zhang, Liang-Liang.,...&Wang, Guo-Dong.(2024).Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds.MOLECULAR BIOLOGY AND EVOLUTION,41(7),12. |
| MLA | Wang, Shi-Zhi,et al."Historic dog Furs Unravel the Origin and Artificial Selection of Modern Nordic Lapphund and Elkhound dog Breeds".MOLECULAR BIOLOGY AND EVOLUTION 41.7(2024):12. |
入库方式： OAI收割
来源：古脊椎动物与古人类研究所
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