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High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China

文献类型：期刊论文

作者Lu, Xin6; Luo, Ming7; Wang, Mengyu1,6; Zhou, Zhemin2,6; Xu, Jialiang3; Li, Zhenpeng6; Peng, Yao6; Zhang, Yuan6; Ding, Fangyu5; Jiang, Dong5
刊名NATURE COMMUNICATIONS
出版日期2024-11-26
卷号15期号:1页码:11
DOI10.1038/s41467-024-54405-9
产权排序6
英文摘要Food workers have frequent contact with unprocessed foods, but their carriage of Salmonella and potential influence on public health have not been comprehensively assessed. We investigated Salmonella carriage among food workers compared with non-food workers based on occupational health screening of 260,315 asymptomatic workers over an 8-year surveillance period in Yulin, China. We confirmed that healthy carriers serve as natural reservoirs for Salmonella, with higher carriage rates in food workers than non-food workers. The isolates from food workers also exhibited greater serovar diversity and likely higher levels of antimicrobial resistance than those from non-food workers. Factors such as meteorological, social, and hygiene factors potentially influenced the carriage rate. Genomic analysis revealed a consistent increase in antimicrobial resistance genes among Salmonella isolates over the study period, with the majority of these antimicrobial resistance genes located on plasmids. Additionally, we identified numerous closely related bacterial clusters, which might reflect clusters of hidden local foodborne infections. This study underscores the elevated risk posed by food workers in the persistence and dissemination of Salmonella as vectors/fomites. Enhanced monitoring and targeted interventions in this group may reduce the dissemination of pathogens and antimicrobial resistance genes. Salmonella is a significant cause of gastrointestinal infection and asymptomatic carriage can contribute to transmission. Here, the authors investigate the prevalence of asymptomatic carriage of Salmonella in Yulin, China through occupational health screening and find that carriage was higher in food workers.
WOS关键词PREVALENCE ; ESTABLISHMENT ; METAANALYSIS
资助项目National Natural Science Foundation of China (National Science Foundation of China)[2022YFC2303900] ; National Key Research and Development Program of China[22193064] ; Major Projects of the National Natural Science Foundation of China[32370099] ; National Natural Science Foundation of China
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001364813000003
出版者NATURE PORTFOLIO
资助机构National Natural Science Foundation of China (National Science Foundation of China) ; National Key Research and Development Program of China ; Major Projects of the National Natural Science Foundation of China ; National Natural Science Foundation of China
源URL[http://ir.igsnrr.ac.cn/handle/311030/211582]  
专题资源利用与环境修复重点实验室_外文论文
通讯作者Wu, Yannong; Kan, Biao
作者单位1.Shandong Univ, Cheeloo Coll Med, Sch Publ Hlth, Jinan 250012, Shandong, Peoples R China
2.Soochow Univ, Suzhou Med Coll, Key Lab Alkene carbon Fibres based Technol & Appli, MOE Key Lab Geriatr Dis & Immunol,Canc Inst, Suzhou 215123, Peoples R China
3.Beijing Technol & Business Univ, Sch Light Ind Sci & Engn, Beijing 100048, Peoples R China
4.China Natl Ctr Food Safety Risk Assessment, NHC Key Lab Food Safety Risk Assessment, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China
6.Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Natl Key Lab Intelligent Tracking & Forecasting In, Beijing 102206, Peoples R China
7.Yulin Ctr Dis Control & Prevent, Yulin 537000, Guangxi, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Xin,Luo, Ming,Wang, Mengyu,et al. High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China[J]. NATURE COMMUNICATIONS,2024,15(1):11.
APA Lu, Xin.,Luo, Ming.,Wang, Mengyu.,Zhou, Zhemin.,Xu, Jialiang.,...&Kan, Biao.(2024).High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China.NATURE COMMUNICATIONS,15(1),11.
MLA Lu, Xin,et al."High carriage and possible hidden spread of multidrug-resistant Salmonella among asymptomatic workers in Yulin, China".NATURE COMMUNICATIONS 15.1(2024):11.

入库方式： OAI收割

来源：地理科学与资源研究所

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