Green synthesis and physical characterization of zinc oxide nanoparticles (ZnO NPs) derived from the methanol extract of Euphorbia dracunculoides Lam. (Euphorbiaceae) with enhanced biosafe applications
文献类型：期刊论文
| 作者 | Khattak, Umbreen9; Jan, Samin9; Ullah, Rehman1; Haq, Tauheed ul1; Khan, Muhammad Nauman2,9; Iqbal, Majid3,6; Kaplan, Alevcan7; Rehman, Abdul8; Elsadek, Mohamed Farouk5; Ajmal Ali, Mohammad4 |
| 刊名 | GREEN PROCESSING AND SYNTHESIS
 |
| 出版日期 | 2024-10-17 |
| 卷号 | 13期号:1页码:19 |
| 关键词 | ED-ZnO NPs GC-MS E. dracunculoides hepatoprotective potential anticancer |
| ISSN号 | 2191-9542 |
| DOI | 10.1515/gps-2024-0119 |
| 产权排序 | 6 |
| 英文摘要 | Euphorbia dracunculoides Lam. possesses significant biological potential due to its rich bioactive compounds. To enhance this potential, zinc oxide nanoparticles (ZnO NPs) were synthesized using the methanolic extract of E. dracunculoides, exploiting ZnO NPs' superior physiochemical properties and bioavailability. The synthesis of ZnO NPs was confirmed through UV-Vis spectroscopy (with an absorption maximum at 368 nm), X-ray diffraction (crystalline nature), Fourier transform infrared spectroscopy (functional groups involved in Zn2+ reduction), scanning electron microscopy (rod-shaped and triangular morphologies, average size 79 nm), and EDX (presence of Zn and O). The ED-ZnO NPs exhibited dose-dependent cytotoxicity against U87 cells (IC50: 229.51 mu g center dot mL(-1)) and anti-leishmanial activity against Leishmania tropica promastigotes (IC50: 9.11 mu g center dot mL(-1)). Additionally, in vivo studies demonstrated significant antihyperlipidemic effects, with decreased cholesterol, triglyceride, and low-density lipoprotein levels, and increased high-density lipoprotein levels. ED-ZnO NPs also normalized alkaline phosphatase, alanine transaminase, aspartate transaminase, total bilirubin, creatinine, urea, and glucose levels compared to controls. Overall, ED-ZnO NPs effectively enhance the bioactive compounds' efficacy in treating various disorders. |
| WOS关键词 | ANTILEISHMANIAL ACTIVITY ; FACILE FABRICATION ; BIOSYNTHESIS ; CYTOTOXICITY ; DRUGS ; FRUIT |
| 资助项目 | King Saud University,Riyadh, Saudi Arabia[RSP2024R306] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001338254900001 |
| 出版者 | DE GRUYTER POLAND SP Z O O |
| 资助机构 | King Saud University,Riyadh, Saudi Arabia |
| 源URL | [http://ir.igsnrr.ac.cn/handle/311030/209723]  |
| 专题 | 生态系统网络观测与模拟院重点实验室_外文论文 |
| 通讯作者 | Kaplan, Alevcan; Rehman, Abdul |
| 作者单位 | 1.Univ Peshawar, Dept Bot, Peshawar 25100, Pakistan 2.Univ Publ Sch, Univ Peshawar, Peshawar 25120, Pakistan 3.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Key Lab Ecosyst Network Observat & Modeling, 11A Datun Rd, Beijing 100101, Peoples R China 4.King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia 5.King Saud Univ, Coll Sci, Dept Biochem, PO 2455, Riyadh 11451, Saudi Arabia 6.Univ Chinese Acad Sci UCAS, Beijing 100049, Peoples R China 7.Batman Univ, Sason Vocat Sch, Dept Crop & Anim Prod, TR-72060 Batman, Turkiye 8.Univ Strathclyde, Dept Phys, Glasgow G4 0NG, Scotland 9.Islamia Coll, Dept Bot, Peshawar, Pakistan |
| 推荐引用方式 GB/T 7714 | Khattak, Umbreen,Jan, Samin,Ullah, Rehman,et al. Green synthesis and physical characterization of zinc oxide nanoparticles (ZnO NPs) derived from the methanol extract of Euphorbia dracunculoides Lam. (Euphorbiaceae) with enhanced biosafe applications[J]. GREEN PROCESSING AND SYNTHESIS,2024,13(1):19. |
| APA | Khattak, Umbreen.,Jan, Samin.,Ullah, Rehman.,Haq, Tauheed ul.,Khan, Muhammad Nauman.,...&Ajmal Ali, Mohammad.(2024).Green synthesis and physical characterization of zinc oxide nanoparticles (ZnO NPs) derived from the methanol extract of Euphorbia dracunculoides Lam. (Euphorbiaceae) with enhanced biosafe applications.GREEN PROCESSING AND SYNTHESIS,13(1),19. |
| MLA | Khattak, Umbreen,et al."Green synthesis and physical characterization of zinc oxide nanoparticles (ZnO NPs) derived from the methanol extract of Euphorbia dracunculoides Lam. (Euphorbiaceae) with enhanced biosafe applications".GREEN PROCESSING AND SYNTHESIS 13.1(2024):19. |
入库方式： OAI收割
来源：地理科学与资源研究所
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