It is well-known that the equilibrium isotope fractionation of mercury (Hg) includes classical mass-dependent fractionations (MDFs) and nuclear volume effect (NVE) induced mass-independent fractionations (MIFs). However, the effect of the NVE on these kinetic processes is not known. The total fractionations (MDFs + NVE-induced MIFs) of several representative Hg-incorporated substances were selected and calculated with ab initio calculations in this work for both equilibrium and kinetic processes. NVE-induced MIFs were calculated with scaled contact electron densities at the nucleus through systematic evaluations of their accuracy and errors using the Gaussian09 and DIRAC19 packages (named the electron density scaling method). Additionally, the NVE-induced kinetic isotope effect (KIE) of Hg isotopes are also calculated with this method for several representative Hg oxidation reactions by chlorine species. Total KIEs for ²⁰²Hg/¹⁹⁸Hg ranging from − 2.27‰ to 0.96‰ are obtained. Three anomalous ²⁰²Hg-enriched KIEs (δ²⁰²Hg/¹⁹⁸Hg = 0.83‰, 0.94‰, and 0.96‰,) caused by the NVE are observed, which are quite different from the classical view (i.e., light isotopes react faster than the heavy ones). The electron density scaling method we developed in this study can provide an easier way to calculate the NVE-induced KIEs for heavy isotopes and serve to better understand the fractionation mechanisms of mercury isotope systems.