Immunostimulatory effect of quaternary degree and acetyl group of quaternized chitosan on macrophages RAW 264.7
文献类型：CNKI期刊论文
| 作者 | Xiaomin LI; Rong'e XING; Chaojie XU ; Song LIU; Yukun QIN; Kecheng LI; Huahua YU; Pengcheng LI
|
| 发表日期 | 2022-05-15 |
| 出处 | Journal of Oceanology and Limnology
 |
| 关键词 | quaternized chitosan fully deacetylated quaternized chitosan degree of quaternization Immunostimulatory activity |
| 英文摘要 | Hydroxypropyltrimetrhl ammonium chloride chitosan(HACC) and hydroxypropyltrimethyl ammonium chloride fully deacetylated chitosan(De-HACC) were synthesized with various degrees of substitution by altering the ratio of chitosan to glycidyl trimethyl-ammonium chloride(GTMAC).The effects of the quaternary ammonium degree and the acetyl group of these polymers on immunostimulatory activities were detected in RAW 264.7 cells.The expression levels of nitrogen oxide(NO),interleukin-6(IL-6) and tumor necrosis factor(TNF-α) were compared.Results show that the removal of acetyl groups in chitosan obviously improved the degree of substitution of quaternary ammonium salts.In addition,HACC and De-HACC were capable of promoting immunological activity in a substitution-dependent manner;HACC was positively correlated,and De-HACC was negatively correlated.Among tested ratios,HACC-3 0% and De-HACC-54% performed better than the others,and De-HACC-54% performed the best.Generally,quaternized chitosan possesses immunostimulatory activity,which is related to the degree of quaternization and the acetyl group. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by Key Deployment Projects of the Marine Science Research Center of Chinese Academy of Sciences (No.COMS2020J04) |
| 卷 | v.40期:03页:332-342 |
| 语种 | 英文; |
| 分类号 | R392 |
| ISSN号 | 2096-5508 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/187425]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.CASandShandongProvinceKeyLaboratoryofExperimentalMarineBiology,CenterforOceanMega-Science,InstituteofOceanology,ChineseAcademyofSciences 2.LaboratoryforMarineDrugsandBioproducts,PilotNationalLaboratoryforMarineScienceandTechnology(Qingdao) 3.UniversityofChineseAcademyofSciences |
| 推荐引用方式 GB/T 7714 | Xiaomin LI,Rong'e XING,Chaojie XU,et al. Immunostimulatory effect of quaternary degree and acetyl group of quaternized chitosan on macrophages RAW 264.7. 2022. |
入库方式： OAI收割
来源：海洋研究所
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