Synthesis, characterization, and antioxidant activity of carboxymethyl chitosan derivatives containing sulfonium salt
文献类型：CNKI期刊论文
| 作者 | Xueqi SUN; Jingjing ZHANG; Yingqi MI; Qin MIAO; Wenqiang TAN; Qing LI; Zhanyong GUO |
| 发表日期 | 2022-01-15 |
| 出处 | Journal of Oceanology and Limnology
 |
| 关键词 | antioxidant activity carboxymethyl chitosan derivative sulfonium salts structural characteristics/synthesis |
| 英文摘要 | To improve the solubility and bioactivity of chitosan, a new class of carboxymethyl chitosan derivatives possessing sulfonium salts was successfully designed and synthesized, including Methyl sulfide carboxymethyl chitosan(MCMCS), Ethyl sulfide carboxymethyl chitosan(ECMCS), Propyl sulfide carboxymethyl chitosan(PCMCS), and Butyl sulfide carboxymethyl chitosan(BCMCS). To determine the structure of the new class of the derivatives, methods of the Fourier transform infrared spectroscopy(FT-IR),~1H nuclear magnetic resonance spectrometer( ~1H NMR), and ~(13)C nuclear magnetic resonance spectrometer( ~(13)C NMR) were used. Moreover, the antioxidant activity of the derivatives for three types of free radicals,i.e., hydroxyl radical, superoxide radical, and 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical was evaluated in vitro. In addition, the L929 cells were adopted to test the cytotoxicity of chitosan and its derivatives by CCK-8 assay. The class of the carboxymethyl chitosan derivatives showed a strong scavenging ability against the three free radicals at 1.6 mg/mL, with scavenging rate of over 70% and some up to 100%. At this high rate, the overall cell viability in the toxicity test reached more than 80%, indicating that the synthetic derivative had a little cytotoxicity. The results show that the introduction of carboxymethyl group to chitosan increased the water-solubility of chitosan, and the combination of sulfonate ions with dif ferent chain lengths further enhanced the antioxidant activity of chitosan. Therefore, the sulfonium-containing carboxymethyl chitosan derivatives had excellent bioactivity with good application prospects in food, biomedicine, and medical fields. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the National Key R&D Program of China (No. 2019YFD0900705) ; the Key Deployment Projects of the Marine Science Research Center of the Chinese Academy of Sciences (No. COMS2020J04) ; the Natural Science Foundation of Shandong Province of China (No. ZR2019BD064) |
| 卷 | v.40期:01页:287-298 |
| 语种 | 英文; |
| 分类号 | O636.1 |
| ISSN号 | 2096-5508 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/187522]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.KeyLaboratoryofCoastalBiologyandBioresourceUtilization,YantaiInstituteofCoastalZoneResearch,ChineseAcademyofSciences 2.UniversityofChineseAcademyofSciences 3.CenterforOceanMega-Science,ChineseAcademyofSciences |
| 推荐引用方式 GB/T 7714 | Xueqi SUN,Jingjing ZHANG,Yingqi MI,et al. Synthesis, characterization, and antioxidant activity of carboxymethyl chitosan derivatives containing sulfonium salt. 2022. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。