Triterpenoid saponin biosynthesis genes and their expression patterns during the development of sea cucumber Apostichopus japonicus
文献类型：CNKI期刊论文
| 作者 | Yujia YANG; Xiaoni LI; Lina SUN |
| 发表日期 | 2021-11-15 |
| 出处 | Journal of Oceanology and Limnology
 |
| 关键词 | triterpene saponin biosynthesis sea cucumber enzyme expression development |
| 英文摘要 | Sea cucumbers are echinoderm species with a leathery skin and an elongated body.Natural compounds,including saponins,have been previously isolated from sea cucumber.The maj ority of saponins derived from this organism typically belong to the triterpene glycosides,which exhibit various biological effects(e.g.,antifungal,cytotoxic,hemolytic,and cytostatic immunomodulatory activities).In the present study,30 saponin biosynthesis enzymes,namely 2 AACTs,2 FPSs,2 HMGSs,2 OSCs,1 SS,2 SEs,and 19 UGTs,were found in the genome of sea cucumber Apostichopus japonicus.Compared with upstream saponin biosynthesis enzymes(i.e.,AACTs,FPSs,HMGSs,OSCs,and SSs),the downstream saponin biosynthesis enzymes(SEs and UGTs) shared lower amino acid sequence similarity with the corresponding genes in other echinoderms.It was proposed that the enzyme structures comprised both α-helices andβ-sheets.Notably,only a low percentage of β-sheets were present in FPSs,OSCs,and SS.The saponin biosynthesis enzymes showed dynamic expression patterns during five critical developmental stages of A.japonicus(fertilized oocytes,blastula,gastrula,doliolaria,and penractula).The present study involved elucidation of putative saponin biosynthesis pathways in sea cucumber and provides a valuable platform for further investigation of saponin biosynthesis in echinoderms. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the National Key R&D Program of China (No.2018YFD0900105) ; the Agricultural Seed Project of Shandong Province(No.2017LZGC010) ; the Youth Innovation Promotion Association CAS (No.2019209) |
| 卷 | v.39期:06页:297-310 |
| 语种 | 英文; |
| 分类号 | S917.4 |
| ISSN号 | 2096-5508 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/187586]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.CASKeyLaboratoryofMarineEcologyandEnvironmentalSciences,InstituteofOceanology,ChineseAcademyofSciences 2.LaboratoryforEvolutionandDevelopment,InstituteofEvolutionandMarineBiodiversity,OceanUniversityofChina |
| 推荐引用方式 GB/T 7714 | Yujia YANG,Xiaoni LI,Lina SUN. Triterpenoid saponin biosynthesis genes and their expression patterns during the development of sea cucumber Apostichopus japonicus. 2021. |
入库方式： OAI收割
来源：海洋研究所
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