Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans
文献类型：CNKI期刊论文
| 作者 | Zhongshan ZHANG; Xiaomei WANG; Yongliang PAN; Zhanqi WANG; Zhengshun WEN; Feng LIU; Genxiang MAO |
| 发表日期 | 2021-03-15 |
| 出处 | Journal of Oceanology and Limnology
 |
| 关键词 | Pyropia haitanensis polysaccharide protein aggregation Caenorhabditis elegans |
| 英文摘要 | Pyropia haitanensis poly saccharide(LP) have been found for having many excellent functions such as anti-aging.Using Caenorhabditis elegans models,we evaluated the anti-aging activity of LP by observing the lifespan,reproduction,pharyngeal pumping,stress response,quantitative fluorescence of poly glutamic acid,and nuclear localization of DAP-16 of worms.The results reveal that LP could extend the adult lifespan of wild-type and polyQ nematodes,indicating a connection of its anti-aging benefit with the toxicity-suppressing effect The number of polyglutamic acid aggregates in high concentration groups decreased by 24.39%(P<0.05) to the control.The high-dose group strongly induced DAP-16 nuclear translocation over intermediate and cytosolic localizations compared with the control(P<0.001).Therefore,we believe that LP could extend the lifespan and reduce the protein aggregation in C.elegans through nuclear DAF-16::GFP expression. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | the National Natural Science Foundation of China (Nos. 31700307, 41876165) ; the Science and Technology Project of Huzhou (No. 2017ZD2017) ; the Key Research Program of Frontier Sciences ; Chinese Academy of Sciences (No. QYZDB-SSW-DQC023) |
| 卷 | v.39期:02页:359-367 |
| 语种 | 英文; |
| 分类号 | Q95-33 |
| ISSN号 | 2096-5508 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/187828]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.KeyLaboratoryofVectorBiologyandPathogenControlofZhejiangProvince,HuzhouUniversity,HuzhouCentralHospital 2.ZhejiangProvincialEngineeringTechnologyResearchCenterofMarineBiomedicalProducts,SchoolofFoodScienceandPharmaceutics,ZhejiangOceanUniversity 3.CASKeyLaboratoryofMarineEcologyandEnvironmentalSciences,InstituteofOceanology,ChineseAcademyofSciences 4.ZhejiangProvincialKeyLabofGeriatrics,DepartmentofGeriatrics,ZhejiangHospital |
| 推荐引用方式 GB/T 7714 | Zhongshan ZHANG,Xiaomei WANG,Yongliang PAN,et al. Pyropia haitanensis polysaccharide extends lifespan by inhibiting protein aggregation in Caenorhabditis elegans. 2021. |
入库方式： OAI收割
来源：海洋研究所
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