Marine bacterial surfactin CS30-2 induced necrosis-like cell death in Huh7.5 liver cancer cells
文献类型：CNKI期刊论文
| 作者 | ZHOU Shengnan; LIU Ge; WU Shimei |
| 发表日期 | 2020-05-15 |
| 出处 | Journal of Oceanology and Limnology
 |
| 关键词 | Bacillus surfactin anticancer activity reactive oxygen species(ROS) |
| 英文摘要 | Marine bacterial strain Bacillus sp. CS30 exhibited high anticancer activity against Huh7.5 human liver cancer. We purified the corresponding anticancer agent by sequential acidic precipitation, methanol extraction, Sephadex LH-20 chromatography, and reversed phase high-performance liquid chromatography(RP-HPLC), then analyzed it in mass spectrometry. Based on the results of purification and mass spectrometry, we deduced that the anticancer agent was the same component as our previously purified antifungal agent surfactin CS30-2. However, to the best of our knowledge, this is the first report on the surfactin possessing both antifungal and anticancer activities. Surfactin CS30-2 was demonstrated to exhibit high anticancer activity in a dose-dependent manner against Huh7.5 liver cancer cells. Further investigation showed that surfactin CS30-2 induced the increased generation of reactive oxygen species(ROS) and severe disruption of cell membrane, thus leading to cell death. However, unlike previously reported surfactins, surfactin CS30-2 caused cancer cell death via necrosis instead of apoptosis. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the National Natural Science Foundation of China (No. 31600035) to WU Shimei |
| 卷 | v.38期:03页:237-244 |
| 语种 | 英文; |
| 分类号 | R735.7 |
| ISSN号 | 2096-5508 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/188231]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.KeyLaboratoryofExperimentalMarineBiology,InstituteofOceanology,ChineseAcademyofSciences 2.CollegeofLifeSciences,QingdaoUniversity 3.LaboratoryforMarineBiologyandBiotechnology,QingdaoNationalLaboratoryforMarineScienceandTechnology |
| 推荐引用方式 GB/T 7714 | ZHOU Shengnan,LIU Ge,WU Shimei. Marine bacterial surfactin CS30-2 induced necrosis-like cell death in Huh7.5 liver cancer cells. 2020. |
入库方式： OAI收割
来源：海洋研究所
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