Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery
文献类型：CNKI期刊论文
| 作者 | YU Weiting; ZHANG Demeng; LIU Xiudong; WANG Yunhong; TONG Jun; ZHANG Mengxue; MA Xiaojun |
| 发表日期 | 2019-05-15 |
| 出处 | Journal of Oceanology and Limnology
 |
| 关键词 | hydrophobic modification sodium alginate-vinyl acetate amphiphilic Alg-g-PVAc/chitosan microcapsules drug delivery |
| 英文摘要 | To overcome the fast or burst release of hydrophilic drugs from hydrophilic alginate-based carriers, hydrophobic molecule(vinyl acetate, VAc) was grafted on alginate(Alg), which was further used to prepare drug carriers. Amphiphilic Alg-g-PVAc hydrogel beads were firstly prepared by emulsification/internal gelation technique for the loading of bovine serum albumin(BSA). Then, chitosan was coated on the surface of beads to form novel amphiphilic Alg-g-PVAc/chitosan(Alg-g-PVAc/CS) microcapsules.The BSA-loading amphiphilic Alg-g-PVAc/chitosan(Alg-g-PVAc/CS) microcapsules display similar morphology and size to the hydrophilic alginate/chitosan(AC) microcapsules. However, the drug loading and loading efficiency of BSA in Alg-g-PVAc/CS microcapsules are higher, and the release rate of BSA from Alg-g-PVAc/CS microcapsules is slower. The results demonstrate that the introduction of hydrophobic PVAc on alginate can effectively help retard the release of BSA, and the higher degree of substitution is,the slower the release rate is. In addition, the complex membrane can also be adjusted to delay the release of BSA. As a whole, amphiphilic sodium alginate-vinyl acetate/CS microparticles could be developed for macromolecular drug delivery. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the National Natural Science Foundation of China(No.21276033) ; the Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances(Nos.SKL-BASS1711,SKL-BASS1707) ; the National Undergraduates Innovation and Entrepreneurship Training Program of China(No.201711258000001) |
| 卷 | v.37期:03页:79-86 |
| 语种 | 英文; |
| 分类号 | R943 |
| ISSN号 | 2096-5508 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/188568]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.StateKeyLaboratoryofBioactiveSeaweedSubstances,QingdaoBrightmoonSeaweedGroupCo.Ltd. 2.DalianInstituteofChemicalPhysics,ChineseAcademyofSciences 3.AffiliatedZhongshanHospitalofDalianUniversity 4.InstituteofOceanology,ChineseAcademyofSciences 5.CollegeofEnvironmentandChemicalEngineering,DalianUniversity,DalianEconomicTechnologicalDevelopmentZone |
| 推荐引用方式 GB/T 7714 | YU Weiting,ZHANG Demeng,LIU Xiudong,et al. Amphiphilic sodium alginate-vinyl acetate microparticles for drug delivery. 2019. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。