Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva
文献类型：CNKI期刊论文
| 作者 | Li RF(李荣锋); Yu HH(于华华) ; Yue Y(岳洋); Liu S(刘松); Xing RE(邢荣娥); Chen XL(陈晓琳); Li PC(李鹏程)
|
| 发表日期 | 2017-07-15 |
| 出处 | Chinese Journal of Oceanology and Limnology
 |
| 关键词 | sulfated polysaccharides sea cucumber Holothuria fuscogliva antioxidant activity anticoagulant activity |
| 英文摘要 | Sea cucumber is a traditional nutritional food and medicinal resource with many bioactive components in China.Holothuria fuscogliva is a big sea cucumber with a rich of bioactive polysaccharides.To investigate the bioactivities of the polysaccharides from sea cucumber H.fuscogliva,we prepared the sulfated polysaccharides(HfP) from sea cucumber H.fuscogliva using a protease hydrolysis method.Antioxidant activities of HfP were investigated,including hydroxyl radical scavenging activity and superoxide radical scavenging activity.And,the anticoagulant activities of HfP were studied,including the activated partial thromboplastin time(APTT),prothrombin time(PT) and thrombin time(TT).The average molecular weight was 1 867.1 Da,with a sulfate content of 20.7%.In addition,the molar ratio of monosaccharide composition of HfP was Man:Rha:Glc A:Glc:Gal:Xyl:Fuc=0.083 6:0.437:0.134:0:1.182:0.748:1.It had a strong antioxidant activity,the hydroxyl and superoxide radical scavenging activity EC_(50) of HfP was 3.74 and 0.037 mg/mL,respectively.It also showed a good anticoagulant activity in our study.The APTT of HfP was much higher than that of heparin sodium,and the PT and TT of HfP was close to that of heparin sodium at a low concentration.Therefore,HfP shows a good antioxidant and anticoagulant activity and it may become a potential candidate of the natural antioxidant and anticoagulant and will have a good application future in health product or medicine industry. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the Science and Technology Service Network Program of Chinese Academy of Sciences(No.KFJ-EW-STS-060) ; the National Special Research Fund for Non-Profit Marine Sector(No.201405038-2) ; the Scientific and Technological Innovation Project ; Financially Supported by Qingdao National Laboratory for Marine Science and Technology(No.2015ASKJ02) |
| 卷 | v.35期:04页:43-49 |
| 语种 | 英文; |
| 分类号 | R285 |
| ISSN号 | 0254-4059 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/189245]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.UniversityofChineseAcademyofSciences 2.KeyLaboratoryofExperimentalMarineBiology,InstituteofOceanology,ChineseAcademyofSciences |
| 推荐引用方式 GB/T 7714 | Li RF,Yu HH,Yue Y,et al. Sulfated polysaccharides with antioxidant and anticoagulant activity from the sea cucumber Holothuria fuscogliva. 2017. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。