Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase
文献类型：CNKI期刊论文
| 作者 | Liu M(刘明); Wei JT(魏鉴腾); Wang H(王惠); Ding LL(丁丽丽); Zhang YY(张玉艳); Lin XK(林秀坤) |
| 发表日期 | 2012-09-15 |
| 出处 | Chinese Journal of Oceanology and Limnology
 |
| 关键词 | Meretrix meretrix Linnaeus angiogenesis NOS nitric oxide(NO) |
| 英文摘要 | Meretrix meretrix Linnaeus has long been used as traditional Chinese medicine in oriental medicine.The angiogentic activity of the extract of M.meretrix was investigated in this study,using human umbilical vein endothelial cells(HUVECs).Extract of M.meretrix Linnaeus(AFG-25) was prepared with acetone and ethanol precipitation,and further separated by Sephadex G-25 column.The results show that AFG-25 promoted proliferation,migration,and capillary-like tube formation in HUVECs,and in the presence of eNOS inhibitor NMA,the tube formation induced by AFG-25 is inhibited significantly.Moreover,AFG25 could also promote the activation of endothelial nitric oxide synthase(eNOS) and the resultant elevation of nitric oxide(NO) production.The results suggested that M.meretrix contains active ingredients with angiogentic activity and eNOS/NO signal pathway is in part involved in the proangiogenesis effect induced by AFG-25. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the Innovative Drug Development Projects of China(Nos. 2009ZX09103-661 and 2009ZX09102) ; the National Natural Science Foundation of China(No.81001396) |
| 卷 | v.30期:05页:14-20 |
| 语种 | 英文; |
| 分类号 | R285 |
| ISSN号 | 0254-4059 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/191129]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.DepartmentofPharmacology,CapitalMedicalUniversity 2.InstituteofOceanology,ChineseAcademyofSciences 3.GraduateUniversityofChineseAcademyofSciences |
| 推荐引用方式 GB/T 7714 | Liu M,Wei JT,Wang H,et al. Extract of Meretrix meretrix Linnaeus induces angiogenesis in vitro and activates endothelial nitric oxide synthase. 2012. |
入库方式： OAI收割
来源：海洋研究所
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