Tissue-specific bioaccumulation and oxidative stress responses in juvenile Japanese flounder (Paralichthys olivaceus) exposed to mercury
文献类型：CNKI期刊论文
| 作者 | Huang W(黄伟); Cao L(曹亮); Ye ZJ(叶振江); Lin LS(林龙山); Chen QZ(陈全震); Dou SZ(窦硕增) |
| 发表日期 | 2012-07-15 |
| 出处 | Chinese Journal of Oceanology and Limnology
 |
| 关键词 | mercury (Hg) antioxidants lipid peroxidation bioaccumulation of metal |
| 英文摘要 | To understand mercury (Hg) toxicity in marine fish, we measured Hg accumulation in juvenile Japanese flounder (Paralichthys olivaceus) and assessed the effects on growth and antioxidant responses. After Hg exposure (control, 5, 40, and 160 μg/L Hg) for 28 d, fish growth was significantly reduced. The accumulation of Hg in fish was dose-dependent and tissue-specific, with the maximum accumulation in kidney and liver, followed by gills, bone, and muscle. Different antioxidants responded differently to Hg exposure to cope with the induction of lipid peroxidation (LPO), which was also tissue-specific and dosedependent. As Hg concentration increased, superoxide dismutase (SOD) and catalase (CAT) activities increased significantly, whereas glutathione S-transferase (GST) activity and glutathione (GSH) levels decreased significantly in the gills. SOD and glutathione peroxidase (GPx) activities and the GSH level increased significantly in the liver. SOD activity and GSH levels increased significantly, but CAT activity decreased significantly with an increase in Hg concentration in the kidney. LPO was induced significantly by elevated Hg in the gills and kidney but was least affected in the liver. Therefore, oxidative stress biomarkers in gills were more sensitive than those in the liver and kidney to Hg exposure. Thus, the gills have potential as bioindicators for evaluating Hg toxicity in juvenile flounder. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the National Natural Science Foundation of China for Creative Research Groups (No. 41121064) ; the National High Technology Research and Development Program of China (863 Program) (No.2009AA09Z401) ; the Knowledge Innovation Program of Chinese Academy of Sciences (No. KZCX2-YW-Q07-02) ; the Public Interest Research Program in Marine Industry from the State Oceanic Administration of China (No. 200905019) |
| 卷 | v.30期:04页:65-75 |
| 语种 | 英文; |
| 分类号 | X174 |
| ISSN号 | 0254-4059 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/191185]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.LaboratoryofMarineEcosystemandBiogeochemistry,SecondInstituteofOceanography,StateOceanicAdministration 2.KeyLaboratoryofMarineEcologyandEnvironmentalSciences,InstituteofOceanology,ChineseAcademyofSciences 3.FisheryCollege,OceanUniversityofChina 4.ThirdInstituteofOceanography,StateOceanicAdministration |
| 推荐引用方式 GB/T 7714 | Huang W,Cao L,Ye ZJ,et al. Tissue-specific bioaccumulation and oxidative stress responses in juvenile Japanese flounder (Paralichthys olivaceus) exposed to mercury. 2012. |
入库方式： OAI收割
来源：海洋研究所
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