Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118
文献类型：CNKI期刊论文
| 作者 | Shang Z(尚卓); Li XM(李晓明); Meng L(孟莉); Li CS(李春顺); Gao SS(高书山); Huang CG(黄才国); Wang BG(王斌贵)
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| 发表日期 | 2012-03-15 |
| 出处 | Chinese Journal of Oceanology and Limnology
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| 关键词 | bioguided isolation deep-sea sediment-derived fungus Penicillium commune xanthocillin X antibacterial activity cytotoxicity |
| 英文摘要 | Bioassay-guided fractionation of the crude extract from Penicillium commune SD-118, a fungus obtained from a deep-sea sediment sample, resulted in the isolation of a known antibacterial compound, xanthocillin X (1), and 14 other known compounds comprising three steroids (2-4), two ceramides (5 and 6), six aromatic compounds (7-12), and three alkaloids (13-15). Xanthocillin X (1) was isolated for the first time from a marine fungus. In the bioassay, xanthocillin X (1) displayed remarkable antimicrobial activity against Staphylococcus aureus and Escherichia coli, and significant cytotoxicity against MCF-7, HepG2, H460, Hela, Du145, and MDA-MB-231 cell lines. Meleagrin (15) exhibited cytotoxicity against HepG2, Hela, Du145, and MDA-MB-231 cell lines. This is the first report of the cytotoxicity of xanthocillin X (1). |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the Ministry of Science and Technology(No.2010CB833802) ; the Knowledge Innovation Program of Chinese Academy of Sciences(No.KSCX2-EW-G-12B) ; the National Natural Science Foundation of China(No.30910103914) |
| 卷 | v.30期:02页:115-124 |
| 语种 | 英文; |
| 分类号 | S917.1 |
| ISSN号 | 0254-4059 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/191334]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.KeyLaboratoryofExperimentalMarineBiology,InstituteofOceanology,ChineseAcademyofSciences 2.GraduateUniversityofChineseAcademyofSciences 3.DepartmentofBiochemistryandMolecularBiology,SecondMilitaryMedicalUniversity |
| 推荐引用方式 GB/T 7714 | Shang Z,Li XM,Meng L,et al. Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118. 2012. |
入库方式： OAI收割
来源：海洋研究所
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