Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)
文献类型：CNKI期刊论文
| 作者 | Zhao HL(赵鹤凌); Yang HS(杨红生) ; Zhao H(赵欢); Liu SL(刘石林); Wang TM(王天明)
|
| 发表日期 | 2012-01-15 |
| 出处 | Chinese Journal of Oceanology and Limnology
 |
| 关键词 | microphthalmia-associated transcription factor (MITF) melanocyte melanosome melanin Apostichopus japonicus |
| 英文摘要 | Albino Apostichopus japonicus occur both in the wild and in captivity. The offspring of albino A. japonicus also suffer from albinism. The formation of melanin in the melanocytes is dependant on microphthalmia-associated transcription factor (MITF). To investigate the role of MITF in controlling albinism, we cloned the full-length MITF cDNA from A. japonicus and compared MITF mRNA expression in albino and normal A. japonicus. In addition, we used light and electron microscopy to compare histological samples of normal and albino A. japonicus. The body wall of albino adults was characterized by significantly lower levels of MITF expression and lower numbers of epidermal melanocytes, which also contained less melanin. In albino juvenile offspring, MITF expression levels were significantly lower 32 d after fertilization and there were fewer, and less developed, epidermal melanocytes. Thus, we conclude that albino A. japonicus have fewer melanocytes and a reduced ability to synthesize melanin, likely because of lower expression of MITF. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the National Natural Science Foundation of China(No. 40976089) ; the National Marine Public Welfare Research Project(No. 200805069) ; the National Science and Technology Support Program of China (No. 2011BAD13B02) ; the Breeding Project of Shandong Province (China) |
| 卷 | v.30期:01页:82-93 |
| 语种 | 英文; |
| 分类号 | S917.4 |
| ISSN号 | 0254-4059 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/191396]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.GraduateUniversityofChineseAcademyofSciences 2.KeyLaboratoryofMarineEcologyandEnvironmentalSciences,InstituteofOceanology,ChineseAcademyofSciences |
| 推荐引用方式 GB/T 7714 | Zhao HL,Yang HS,Zhao H,et al. Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka). 2012. |
入库方式： OAI收割
来源：海洋研究所
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