Synthesis and protein tyrosine phosphatase 1B inhibition activities of two new synthetic bromophenols and their methoxy derivatives
文献类型：CNKI期刊论文
| 作者 | Cui YC(崔永超); Shi DY(史大永); Hu ZQ(胡志强) |
| 发表日期 | 2011-11-15 |
| 出处 | Chinese Journal of Oceanology and Limnology
 |
| 关键词 | protein tyrosine phosphatase 1B inhibition bromophenol derivatives synthesis |
| 英文摘要 | 3-bromo-4,5-bis(2,3-dibromo-4,5-dihydroxybenzyl)-1,2-benzenediol (1) is a natural bromophenol isolated from the red algae Rhodomela confervoides that exhibits significant inhibition against protein tyrosine phosphatase 1B (PTP1B). Based on its activity, we synthesized two new synthetic bromophenols and their methoxy derivatives from vanillin using the structure of natural bromophenol 1 as a scaffold. The structures of these bromophenols were elucidated from 1H NMR, 13C NMR, and high resolution electron ionization mass spectrometry as 2,3-dibromo-1-(2p-bromo-6p-(3q,4q-dimethoxybenzyl)- 3p,4p-dimethoxybenzyl)-4,5-dimethoxybenzene(2),2,3-dibromo-1-(2p-bromo-6p-(2q-bromo-4q,5q-dimethoxy-benzyl)-3p,4p-dimethoxybenzyl)-4,5-dimethoxybenzene(3),3,4-dibromo-5-(2p-bromo-6p-(2q-bromo-4q,5q-dihydroxybenzyl)-3p,4p-dihydroxybenzyl)pyrocatechol(4)and 3,4-dibromo-5-(2p-bromo-6p-(3q,4q-dihydroxybenzyl)-3p,4p-dihydroxybenzyl)pyrocatechol (5).PTP1B inhibition activities of these compounds were evaluated using a colorimetric assay,and compounds 3 and 4 demonstrated interesting activity against PTP1B. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the National Major Research Program of China“The Creation for Significant Innovative Drugs”(No.2009ZX09103-148) ; the Natural Science Foundation of Shandong(No.BS2009YY011) ; the Natural Science Foundation of Qingdao(No.10-3-4-8-2-JCH) ; the Program of Qingdao Shinan District(No.2009-HY-2-14) |
| 卷 | v.29期:06页:93-98 |
| 语种 | 英文; |
| 分类号 | Q51 |
| ISSN号 | 0254-4059 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/191493]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.CollegeofChemistryandMolecularEngineeringQingdaoUniversityofScienceandTechnology 2.InstituteofOceanologyChineseAcademyofSciences |
| 推荐引用方式 GB/T 7714 | Cui YC,Shi DY,Hu ZQ. Synthesis and protein tyrosine phosphatase 1B inhibition activities of two new synthetic bromophenols and their methoxy derivatives. 2011. |
入库方式： OAI收割
来源：海洋研究所
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