Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula
文献类型：CNKI期刊论文
| 作者 | Liu X(刘旭); Li XM(李晓明); Gao LX(高立信); Cui CM(崔传明); Li CS(李春顺); Li J(李佳); Wang BG(王斌贵)
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| 发表日期 | 2011-05-15 |
| 出处 | Chinese Journal of Oceanology and Limnology
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| 关键词 | marine alga Rhodomelaceae Symphyocladia latiuscula bromophenol protein tyrosine phosphatase 1B (PTP1B) |
| 英文摘要 | Previously, we had characterized several structurally interesting brominated phenols from the marine red alga Symphyocladia latiuscula collected from various sites. However, Phytochemical investigations on this species collected from the Weihai coastline of Shandong Province remains blank. Therefore, we characterized the chemical constituents of individuals of this species collected from the region. Eight bromophenols were isolated and identified. Using detailed spectroscopic techniques and comparisons with published data, these compounds were identified as 2,3-dibromo-4,5-dihydroxybenzyl methyl ether (1), 3,5-dibromo-4-hydroxybenzoic acid (2), 2,3,6-tribromo-4,5-dihydroxymethylbenzene (3), 2,3,6-tribromo-4,5-dihydroxybenzaldehyde (4), 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether (5), bis(2,3,6-tribromo-4,5-dihydroxyphenyl)methane (6), 1,2-bis(2,3,6-tribromo-4,5-dihydroxyphenyl)-ethane (7), and 1-(2,3,6-tribromo-4,5-dihydroxybenzyl)-pyrrolidin-2-one (8). Among these compounds, 1 and 2 were isolated for the first time from S. latiuscula. Each compound was evaluated on the ability to inhibit protein tyrosine phosphatase 1B (PTP1B), which is a potential therapeutic target in the treatment of type 2 diabetes. Bromophenols 5, 6, and 7 showed strong activities with IC50 values of 3.9, 4.3, and 3.5 μmol/L, respectively. This study provides further evidence that bromophenols are predominant among the chemical constituents of Symphyocladia, and that some of these compounds may be candidates for the development of anti-diabetes drugs. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the National Natural Science Foundation (No. 30530080) ; the Ministry of Science and Technology of China (Nos. 2007AA09Z402, 2007AA09Z403) ; the Department of Science and Technology of Shandong Province (No. 2006GG2205023) |
| 卷 | v.29期:03页:196-200 |
| 语种 | 英文; |
| 分类号 | Q946 |
| ISSN号 | 0254-4059 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/191707]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.KeyLaboratoryofExperimentalMarineBiology,InstituteofOceanology,ChineseAcademyofSciences 2.GraduateUniversityofChineseAcademyofSciences 3.NationalCenterforDrugScreening,ShanghaiInstituteofMateriaMedica,ChineseAcademyofSciences |
| 推荐引用方式 GB/T 7714 | Liu X,Li XM,Gao LX,et al. Extraction and PTP1B inhibitory activity of bromophenols from the marine red alga Symphyocladia latiuscula. 2011. |
入库方式： OAI收割
来源：海洋研究所
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