Antithrombotic effects of bromophenol,an alga-derived thrombin inhibitor
文献类型：CNKI期刊论文
| 作者 | Shi DY(史大永); Li XH(李晓红); Li J(李敬); Guo SJ(郭书举); Su H(苏华); Fan X(范晓) |
| 发表日期 | 2010-02-15 |
| 出处 | Chinese Journal of Oceanology and Limnology
 |
| 关键词 | thrombin inhibitor antithrombotic effect bromophenol derivative |
| 英文摘要 | Thrombin,the ultimate proteinase of the coagulation cascade,is an attractive target for the treatment of a variety of cardiovascular diseases.A bromophenol derivative named (+)-3-(2,3-dibromo-4,5-dihydroxy-phenyl)-4-bromo-5,6-dihydroxy-1,3-dihydroiso-benzofuran 1,isolated from the brown alga Leathesia nana exhibited significant thrombin inhibitory activity.In this study,we investigated the inhibition of human thrombin in vitro with this bromophenol derivative,and its antithrombotic efficacy in vivo using the arteriovenous shunt model and the ferric chloride-induced arterial thrombosis model in rats.The results show that the bromophenol derivative is a potential inhibitor of thrombin (IC50=1.03 nmol/L).In antithrombotic experiments in vivo,the bromophenol derivative also shows good effect comparing with the control group.These data indicate that the bromophenol derivative is a potential drug for prophylaxis and the treatment of thrombotic diseases. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the National High Technology Research and Development Program of China (863 Program) (No. 2007AA09Z410) ; the National Major Research Program of China “The Creation for Significant Innovative Drugs” (No. 2009ZX09103-148) |
| 卷 | v.28期:01页:98-100 |
| 语种 | 英文; |
| 分类号 | R972 |
| ISSN号 | 0254-4059 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/192265]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.InstituteofOceanology,ChineseAcademyofSciences 2.QingdaoMunicipalHospital |
| 推荐引用方式 GB/T 7714 | Shi DY,Li XH,Li J,et al. Antithrombotic effects of bromophenol,an alga-derived thrombin inhibitor. 2010. |
入库方式： OAI收割
来源：海洋研究所
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