Inhibitory effects and mechanisms of high molecular-weight phlorotannins from Sargassum thunbergii on ADP-induced platelet aggregation
文献类型：CNKI期刊论文
| 作者 | Wei YX(魏玉西); Wang ZY(王长云); Li J(李敬); Guo Q(郭奇); Qi HT(齐宏涛) |
| 发表日期 | 2009-08-15 |
| 出处 | Chinese Journal of Oceanology and Limnology
 |
| 关键词 | high molecular-weight phlorotannins Sargassum thunbergii Kuntze platelet aggregation arachidonic acid metabolism |
| 英文摘要 | We evaluated the effects of high molecular-weight phlorotannins from Sargassum thunbergii(STP) on ADP-induced platelet aggregation and arachidonic acid(AA) metabolism in New Zealand white rabbits and Wistar rats.The inhibition of STP on platelet aggregation was investigated using a turbidimetric method,and the levels of the terminal products of AA metabolism were measured using the corresponding kits for maleic dialdehyde(MDA),thromboxane B2(TXB2) and 6-keto-prostaglandin F1α(6-keto-PGF1α) by colorimetry and radioimmunoassay,as appropriate.We found that STP could inhibit ADP-induced platelet aggregation,and the inhibitory ratio was 91.50% at the STP concentration of 4.0 mg/mL.Furthermore,STP markedly affected AA metabolism by decreasing the synthesis of MDA(P<0.01) and increasing the synthesis of 6-keto-PGF1α,thus changing the plasma TXB2/6-keto-PGF1α balance when the platelets were activated(P<0.01).Therefore,STP altered AA metabolism and these findings partly revealed the molecular mechanism by which STP inhibits ADP-induced platelet aggregation. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | Supported by the National Natural Science Foundation of China (No 30572314) ; the Basic Research Program of Science and Technology,Ministry of Science and Technology of China (2007FY210500) ; the Program of Chinese Offshore Investigation and Assessment,State Oceanic Administration of China (Nos 908-01-ST12 and 908-02-05-04) ; the Science and Technology Planning Project of Qingdao (No 06-2212-JCH) |
| 卷 | v.27期:03页:140-145 |
| 语种 | 英文; |
| 分类号 | R96 |
| ISSN号 | 0254-4059 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/192501]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.KeyLaboratoryofMarineDrugs,MinistryofEducation,SchoolofMedicineandPharmacy,OceanUniversityofChina 2.BiologicalDepartment,QingdaoUniversity 3.InstituteofOceanology,ChineseAcademyofSciences |
| 推荐引用方式 GB/T 7714 | Wei YX,Wang ZY,Li J,et al. Inhibitory effects and mechanisms of high molecular-weight phlorotannins from Sargassum thunbergii on ADP-induced platelet aggregation. 2009. |
入库方式： OAI收割
来源：海洋研究所
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