Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity
文献类型：CNKI期刊论文
| 作者 | Qi HM(綦慧敏); Li DX(李大新); Zhang JJ(张晶晶); Liu L(刘力); Zhang QB(张全斌) |
| 发表日期 | 2008-04-15 |
| 出处 | Chinese Journal of Oceanology and Limnology
 |
| 关键词 | agar Gelidium amansii agaropectin anticoagulation |
| 英文摘要 | Gelidium amansii agar was fractionated on DEAE-cellulose and four fractions were obtained sequentially. The yields of 1.0 mol/L NaCl fraction and 2.5 mol/L NaCl fraction were 2.80% and 2.03%. They are highly sulfated agar, and named as agaropectin with sulfate content being 22.8% and 32.5%, respectively. The anticoagulant experiment results show that agaropectin could effectively prolong the coagulation time in a dose-dependent manner in vitro. Agaropection could be absorbed and effectively prolong the plasma coagulation time in vivo. After intragastric administration at the doses of 100, 200, and 400 mg/kg·d in rats for 15 days, TT (thrombin time), CT (coagulation time), PT (prothrombin time), and APTT (activated partial thromboplastin time) could be effectively prolonged and the plasma Fib level could be significantly lowered. |
| 文献子类 | CNKI期刊论文 |
| 资助机构 | the Innovative Key Project of Chinese Academy of Sciences (KZCX2-YW-209) ; the Department of Science and Technology of Shandong Province (2007BS07004) |
| 期 | 02页:68-71 |
| 语种 | 英文; |
| 分类号 | Q946 |
| ISSN号 | 0254-4059 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/193018]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | InstituteofOceanologyChineseAcademyofSciences,ShandongProvincialPharmaceuticalCo.,InstituteofOceanology,ChineseAcademyofSciences,InstituteofOceanology,ChineseAcademyofSciences,InstituteofOceanology,ChineseAcademyofSciences,,Qingdao266071,ChinaWeifangMedicalUniversity,Weifang261042,China,Jinan250014,China,Qingdao266071,China,Qingdao266071,China,Qingdao266071,China |
| 推荐引用方式 GB/T 7714 | Qi HM,Li DX,Zhang JJ,et al. Study on extraction of agaropectin from Gelidium amansii and its anticoagulant activity. 2008. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。