鱼类白细胞介素1β基因的研究概况
文献类型：CNKI期刊论文
| 作者 | 邱丽华,郭奕惠,张汉华 |
| 发表日期 | 2005-02-28 |
| 出处 | 水产学报
 |
| 关键词 | 细胞因子 白细胞介素1β 鱼类 |
| 英文摘要 | Interleukin-1β(IL-1β) is one of the most pleiotropic cytokines and a central regulator of the immune and inflammatory responses. Interleukin-1β was initially discovered within mice and humans and over the last 10 years has been characterized within a wide variety of animals. The IL-1β plays a key role in the inflammatory process, enhancing cell-mediated immunity by inducing the growth and proliferation of lymphocytes, connective tissue cells, and by stimulating immune and inflammatory response effector cells. As an immunoregulatory cytokine, IL-1β has the potential to enhance the immune response induced by a vaccine and/or to modulate the immune response leading to different effector mechanisms. It is produced by many cell types, including monocytes, macrophages, T and B lymphocytes, fibroblasts, and endothelial and epithelial cells. Expression is induced by a diverse range of stimuli, including mitogens, cytokines, and microbial products. There have been considerable evidences provided by biological cross reaction that fish produce IL-1β during immune responses, and the bioactivity of IL-1 in fish has been known for over a decade. But only since 1999, IL-1β gene has been cloned from the rainbow trout. And from then on, IL-1β gene has been cloned and expressed in many fish confirming that fish produces IL-1β gene during immune responses. In mammals it is produced as an inactive precursor that is processed by interleukin converting enzyme (ICE) to give a biologically active `mature' peptide. There is no signal peptide in IL-1β and its mechanism is unknown. This is the special part of the gene structure of the IL-1β. And through the program analyzing, we found this special structure in fish IL-1β gene. This paper reviews the functions and structure of gene IL-1β and the studies of the gene IL-1β in fish recently. |
| 文献子类 | CNKI期刊论文 |
| 期 | 01页:116-120 |
| 语种 | 中文; |
| 分类号 | S941 |
| ISSN号 | 1000-0615 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/199144]  |
| 专题 | 中国科学院海洋研究所 |
| 作者单位 | 1.中国水产科学研究院南海水产研究所 2.中国水产科学研究院南海水产研究所山东青岛266071中国水产科学研究院南海水产研究所广东广州510300 3.广东广州510300 4.中国科学院海洋研究所实验海洋生物学开放实验室 |
| 推荐引用方式 GB/T 7714 | 邱丽华,郭奕惠,张汉华. 鱼类白细胞介素1β基因的研究概况. 2005. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。