Haemolysins are essential to the pathogenicity of deep-sea Vibrio fluvialis
文献类型：期刊论文
| 作者 | Wang, Yujian3,4,6 ; Luo, Jingchang3,4,5,6; Zhao, Yan2; Zhang, Jian1; Guan, Xiaolu3,4,6; Sun, Li3,4,5,6
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| 刊名 | ISCIENCE
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| 出版日期 | 2024-05-17 |
| 卷号 | 27期号:5页码:15 |
| DOI | 10.1016/j.isci.2024.109558 |
| 通讯作者 | Zhao, Yan(zhaoyan1316@163.com) ; Sun, Li(lsun@qdio.ac.cn) |
| 英文摘要 | Vibrio fluvialis is an emerging foodborne pathogen that produces VFH ( Vibrio fluvialis hemolysin) and BVFH (delta-Vibrio Vibrio fluvialis hemolysin). The function of BVFH is unclear. Currently, no pathogenic V . fluvialis from deep sea has been reported. In this work, a deep-sea V . fluvialis isolate (V13) was examined for pathogenicity. V13 was most closely related to V. fluvialis ATCC 33809, a human isolate, but possessed 262 unique genes. V13 caused lethal infection in fish and induced pyroptosis involving activation of the NLRP3 inflammasome, caspase 1 (Casp1), and gasdermin D (GSDMD). V13 defective in VFH or VFH plus BVFH exhibited significantly weakened cytotoxicity. Recombinant BVFH induced NLRP3-Casp1GSDMD-mediated pyroptosis in a manner that depended on K+ + efflux and intracellular Ca2+ 2+ accumulation. BVFH bound several plasma membrane lipids, and these bindings were crucial for BVFH cytotoxicity. Together these results provided new insights into the function of BVFH and the virulence mechanism of V. fluvialis. . |
| WOS关键词 | NLRP3 INFLAMMASOME ; SP NOV. ; CHOLERAE ; INFECTIONS ; PYROPTOSIS |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050402] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA22050403] ; Innovation Research Group Project of the National Natural Science Foundation of China[42221005] ; Shandong Postdoctoral Science Foundation[SDCX-ZG-202303040] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001290486700001 |
| 出版者 | CELL PRESS |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/197571]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Zhao, Yan; Sun, Li |
| 作者单位 | 1.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China 2.Tsinghua Univ, Tsinghua Peking Joint Ctr Life Sci, Sch Med, Beijing 100084, Peoples R China 3.Chinese Acad Sci, Qingdao, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 5.Univ Chinese Acad Sci, Coll Marine Sci, Beijing 100049, Peoples R China 6.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yujian,Luo, Jingchang,Zhao, Yan,et al. Haemolysins are essential to the pathogenicity of deep-sea Vibrio fluvialis[J]. ISCIENCE,2024,27(5):15. |
| APA | Wang, Yujian,Luo, Jingchang,Zhao, Yan,Zhang, Jian,Guan, Xiaolu,&Sun, Li.(2024).Haemolysins are essential to the pathogenicity of deep-sea Vibrio fluvialis.ISCIENCE,27(5),15. |
| MLA | Wang, Yujian,et al."Haemolysins are essential to the pathogenicity of deep-sea Vibrio fluvialis".ISCIENCE 27.5(2024):15. |
入库方式： OAI收割
来源：海洋研究所
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