Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo
文献类型：期刊论文
| 作者 | Zhou, Shilin3; Sun, Yuxuan3; Wang, Kaidi3; Gao, Xintao3; Dong, Kehong3; Wang, Jing2 ; Wu, Xiaochen3; Guo, Chuanlong1,3
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| 刊名 | FOOD AND CHEMICAL TOXICOLOGY
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| 出版日期 | 2024-02-01 |
| 卷号 | 184页码:11 |
| 关键词 | Oxaliplatin Intestinal toxicity Polydatin DNA damage cGAS-STING |
| ISSN号 | 0278-6915 |
| DOI | 10.1016/j.fct.2023.114427 |
| 通讯作者 | Wu, Xiaochen(wxcguest@126.com) ; Guo, Chuanlong(guochuanlong@qust.edu.cn) |
| 英文摘要 | Oxaliplatin (OXL) is a first-line drug for the treatment of colon cancer, with excellent efficacy. Intestinal toxicity is a common side effect of OXL, with unclear pathogenesis and a lack of effective treatment strategies. Polydatin (PD) has anti-inflammatory and antioxidant activities and is a potential drug for treating intestinal diseases, but its poor water solubility limits its application. In this study, polyvinylpyrrolidone (PVP) was used as a carrier to prepare nanoparticles loaded with PD (PVP-PD), with a particle size of 92.42 nm and exhibiting sustained release properties. In vitro results showed that PVP-PD protected NCM460 cells from OXL induced injury, mitochondrial membrane potential (MMP) disruption, and accumulation of reactive oxygen species (ROS). The in vivo results demonstrated the protective effect of PVP-PD on intestinal toxicity induced by OXL, such as alleviating weight loss and colon length reduction induced by OXL. Both in vivo and in vitro mechanisms indicated that OXL induced DNA damage and activated the cGAS-STING pathway, further inducing the expression of inflammatory factors such as IL-1 beta and TNF-alpha. PVP-PD alleviated the aforementioned changes induced by OXL by inhibiting the DNA damage-cGAS-STING pathway. In summary, our study demonstrated that the DNA damage-cGAS-STING pathway was involved in OXL induced intestinal toxicity, and PVP-PD provided a potential strategy for treating OXL induced intestinal toxicity. |
| WOS关键词 | CHEMOTHERAPY-INDUCED NAUSEA ; OXIDATIVE STRESS ; STING PATHWAY ; CGAS ; DNA ; CANCER ; INJURY ; 2ND-MESSENGER ; SENESCENCE ; MANAGEMENT |
| 资助项目 | National Natural Science Foundation of China[22307060] ; Shandong Provincial Natural Science Foundation[ZR2020QH359] ; Open Fund of CAS ; Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences[KF2022NO06] ; Program for Young Talents of Science and Technology in Universities of Inner Mongolia[NJYT-18-B29] ; Doctoral Scientific Research Foundation of Inner Mongolia[BTTCRCQD2018001] |
| WOS研究方向 | Food Science & Technology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:001298946100001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/198167]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Wu, Xiaochen; Guo, Chuanlong |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China 2.Baotou Teachers Coll, Dept Biol Sci & Technol, Baotou 014030, Peoples R China 3.Qingdao Univ Sci & Technol, Coll Chem Engn, Dept Pharm, Qingdao 266042, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Shilin,Sun, Yuxuan,Wang, Kaidi,et al. Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo[J]. FOOD AND CHEMICAL TOXICOLOGY,2024,184:11. |
| APA | Zhou, Shilin.,Sun, Yuxuan.,Wang, Kaidi.,Gao, Xintao.,Dong, Kehong.,...&Guo, Chuanlong.(2024).Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.FOOD AND CHEMICAL TOXICOLOGY,184,11. |
| MLA | Zhou, Shilin,et al."Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo".FOOD AND CHEMICAL TOXICOLOGY 184(2024):11. |
入库方式： OAI收割
来源：海洋研究所
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