Multi-Omics Integrative Analysis to Reveal the Impacts of Shewanella algae on the Development and Lifespan of Marine Nematode Litoditis marina
文献类型：期刊论文
| 作者 | Xue, Yiming1,2,3,4 ; Xue, Beining1,2,3,4; Zhang, Liusuo1,2,4
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| 出版日期 | 2024-08-01 |
| 卷号 | 25期号:16页码:22 |
| 关键词 | Litoditis marina development lifespan Shewanella algae Escherichia coli OP50 transcriptomics metabolomics |
| ISSN号 | 1661-6596 |
| DOI | 10.3390/ijms25169111 |
| 通讯作者 | Zhang, Liusuo(lzhang@qdio.ac.cn) |
| 英文摘要 | Understanding how habitat bacteria affect animal development, reproduction, and aging is essential for deciphering animal biology. Our recent study showed that Shewanella algae impaired Litoditis marina development and lifespan, compared with Escherichia coli OP50 feeding; however, the underlying mechanisms remain unclear. Here, multi-omics approaches, including the transcriptome of both L. marina and bacteria, as well as the comparative bacterial metabolome, were utilized to investigate how bacterial food affects animal fitness and physiology. We found that genes related to iron ion binding and oxidoreductase activity pathways, such as agmo-1, cdo-1, haao-1, and tdo-2, were significantly upregulated in L. marina grown on S. algae, while extracellular structural components-related genes were significantly downregulated. Next, we observed that bacterial genes belonging to amino acid metabolism and ubiquinol-8 biosynthesis were repressed, while virulence genes were significantly elevated in S. algae. Furthermore, metabolomic analysis revealed that several toxic metabolites, such as puromycin, were enriched in S. algae, while many nucleotides were significantly enriched in OP50. Moreover, we found that the "two-component system" was enriched in S. algae, whereas "purine metabolism" and "one-carbon pool by folate" were significantly enriched in E. coli OP50. Collectively, our data provide new insights to decipher how diet modulates animal fitness and biology. |
| WOS关键词 | CAENORHABDITIS-ELEGANS ; C. ELEGANS ; INTERACTION NETWORKS ; RIBOSOMAL-RNA ; VIRULENCE ; PROTEIN ; COLONIZATION ; METABOLISM ; SURVIVAL ; STITCH |
| 资助项目 | National Natural Science Foundation of China[32170537] ; Key deployment project of Centre for Ocean Mega-Research of Science, Chinese Academy of Sciences[COMS2019Q16] ; Chinese Academy of Sciences ; Qingdao Innovation Leadership Program[16-8-3-19-zhc] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001307401500001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/198302]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Zhang, Liusuo |
| 作者单位 | 1.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Yiming,Xue, Beining,Zhang, Liusuo. Multi-Omics Integrative Analysis to Reveal the Impacts of Shewanella algae on the Development and Lifespan of Marine Nematode Litoditis marina[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2024,25(16):22. |
| APA | Xue, Yiming,Xue, Beining,&Zhang, Liusuo.(2024).Multi-Omics Integrative Analysis to Reveal the Impacts of Shewanella algae on the Development and Lifespan of Marine Nematode Litoditis marina.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,25(16),22. |
| MLA | Xue, Yiming,et al."Multi-Omics Integrative Analysis to Reveal the Impacts of Shewanella algae on the Development and Lifespan of Marine Nematode Litoditis marina".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25.16(2024):22. |
入库方式： OAI收割
来源：海洋研究所
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