IL-18 signaling is regulated by caspase 6/8 and IL-18BP in turbot (Scophthalmus maximus)
文献类型：期刊论文
| 作者 | Yu, Chao1,2,3,4 ; Xu, Hang2,4; Jiang, Shuai2,4; Sun, Li1,2,3,5
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| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 出版日期 | 2024-10-01 |
| 卷号 | 278页码:13 |
| 关键词 | Teleost Interleukin 18 Caspase Interleukin 18 receptor Interleukin 18 binding protein Immune defense |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2024.135015 |
| 通讯作者 | Sun, Li(lsun@qdio.ac.cn) |
| 英文摘要 | Interleukin (IL)-18 is synthesized as a precursor that requires intracellular processing to become functionally active. In human, IL-18 is processed by caspase 1 (CASP1). In teleost, the maturation and signal transduction mechanisms of IL-18 are unknown. We identified two IL-18 variants, IL-18a and IL-18b, in turbot. IL-18a, but not IL-18b, was processed by CASP6/8 cleavage. Mature IL-18a bound specifically to IL-18 receptor (IL-18R) alpha-expressing cells and induced IL-18R alpha-IL-18R(3 association. Bacterial infection promoted IL-18a maturation in a manner that required CASP6 activation and correlated with gasdermin E activation. The mature IL-18a induced proinflammatory cytokine expression and enhanced bacterial clearance. IL-18a-mediated immune response was suppressed by IL-18 binding protein (IL-18BP), which functioned as a decoy receptor for IL-18a. IL-18BP also functioned as a pathogen pattern recognition receptor and directly inhibited pathogen infection. Our findings revealed unique mechanism of IL-18 maturation and conserved mechanism of IL-18 signaling and regulation in turbot, and provided new insights into the regulation and function of IL-18 related immune signaling. |
| WOS关键词 | GAMMA-INDUCING FACTOR ; INFLAMMATORY CASPASES ; INTERFERON-GAMMA ; BINDING-PROTEIN ; GENE-EXPRESSION ; INNATE IMMUNITY ; INTERLEUKIN-18 ; ACTIVATION ; CYTOKINE ; TH1 |
| 资助项目 | Science & Technology Innovation Project of Laoshan Laboratory[LSKJ202203000] ; Youth Innovation Promotion Association CAS[2021204] ; China Postdoctoral Science Foundation[2023M743527] ; Taishan Scholar Program of Shandong Province |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001312953900001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/198666]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Sun, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, CAS Ctr Ocean Mega Sci, CAS, Qingdao, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Chinese Acad Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 4.Univ Hlth & Rehabil Sci, Sch Fdn Educ, Qingdao, Peoples R China 5.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Chao,Xu, Hang,Jiang, Shuai,et al. IL-18 signaling is regulated by caspase 6/8 and IL-18BP in turbot (Scophthalmus maximus)[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2024,278:13. |
| APA | Yu, Chao,Xu, Hang,Jiang, Shuai,&Sun, Li.(2024).IL-18 signaling is regulated by caspase 6/8 and IL-18BP in turbot (Scophthalmus maximus).INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,278,13. |
| MLA | Yu, Chao,et al."IL-18 signaling is regulated by caspase 6/8 and IL-18BP in turbot (Scophthalmus maximus)".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 278(2024):13. |
入库方式： OAI收割
来源：海洋研究所
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