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Structural Analysis and Anticoagulant Activity of Fucosylated Glycosaminoglycan from Sea Cucumber Phyllophorus proteus

文献类型：期刊论文

作者Liu, Jingwen1,2,3,4; Geng, Lihua2,3,4; Wang, Jing1,2,3,4; Yue, Yang2,3,4; Wu, Ning1,3,4; Zhang, Quanbin1,2,3,4
刊名FOODS
出版日期2024-09-01
卷号13期号:18页码:14
关键词anticoagulation fucosylated glycosaminogiycan Phyllophorus proteus
DOI10.3390/foods13182889
通讯作者Zhang, Quanbin(qbzhang@qdio.ac.cn)
英文摘要Phyllophorus proteus is a low-value sea cucumber from Indonesia and other tropical peripheral waters. In this study, a fucosylated glycosaminoglycan (FG) was extracted from P. proteus. It consists of GlcA, GalNAc, and Fuc, with a molecular weight of 67.1 kDa. The degraded FG (dFG) was prepared by beta-elimination. Structural analysis revealed that the main chain of dFG was composed of GalNAc and GlcA, linked alternately by beta 1,3 and beta 1,4 glycosidic bonds. The sulfate group was located at the 4 and 6 positions of GalNAc. Fuc was attached to the 3 position of GlcA by an alpha 1,3 glycosidic bond, and the side chain of Fuc exhibited various sulfate substitutions. FG significantly prolonged the coagulation time of APTT, PT, TT, and FIB, surpassing the effect of LMWH, thereby demonstrating its ability to exert anticoagulant effects in both the endogenous and exogenous coagulation pathways. Conversely, dFG had no significant effect on the clotting time of PT, suggesting its lack of impact on the intrinsic coagulation pathway. This study elucidates the structural properties and potent anticoagulant activities of fucosylated glycosaminoglycan from P. proteus.
WOS关键词CHONDROITIN SULFATE ; POLYSACCHARIDES
资助项目Asia Collaboration Project on Development of Ecological Marine Ranching
WOS研究方向Food Science & Technology
语种英语
WOS记录号WOS:001326258900001
出版者MDPI
源URL[http://ir.qdio.ac.cn/handle/337002/199182]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Zhang, Quanbin
作者单位1.Univ Chinese Acad Sci, Beijing 101408, Peoples R China
2.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Jingwen,Geng, Lihua,Wang, Jing,et al. Structural Analysis and Anticoagulant Activity of Fucosylated Glycosaminoglycan from Sea Cucumber Phyllophorus proteus[J]. FOODS,2024,13(18):14.
APA Liu, Jingwen,Geng, Lihua,Wang, Jing,Yue, Yang,Wu, Ning,&Zhang, Quanbin.(2024).Structural Analysis and Anticoagulant Activity of Fucosylated Glycosaminoglycan from Sea Cucumber Phyllophorus proteus.FOODS,13(18),14.
MLA Liu, Jingwen,et al."Structural Analysis and Anticoagulant Activity of Fucosylated Glycosaminoglycan from Sea Cucumber Phyllophorus proteus".FOODS 13.18(2024):14.

入库方式： OAI收割

来源：海洋研究所

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