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Comparative analysis of transcriptomics and metabolomics provides insights into the mechanisms of VP AHPND invasion and hepatopancreatic damage in Litopenaeus vannamei

文献类型：期刊论文

作者Zhao, Zhen1,2,4; Wang, Baojie1,2; Jiang, Keyong1,2; Liu, Mei3; Wang, Lei1,2,4
刊名FISH & SHELLFISH IMMUNOLOGY
出版日期2024-11-01
卷号154页码:13
关键词Acute hepatopancreatic necrosis disease (AHPND) Transcriptome and metabolome Hepatopancreatic damage Metabolic disorder Metabolic disorder
ISSN号1050-4648
DOI10.1016/j.fsi.2024.109920
通讯作者Liu, Mei(mliu_msrisd@126.com) ; Wang, Lei(leiwang@qdio.ac.cn)
英文摘要Acute hepatopancreatic necrosis disease (AHPND) poses significant threats to the global shrimp farming industry; however, its molecular mechanisms remain largely unknown. Previous research has primarily focused on comparisons between infected and non-infected states, limiting our understanding of VPAHPND mechanisms. We integrated transcriptomic and metabolomic analyses to investigate the pathogenic mechanism underpinning AHPND in highly vulnerable post-larvae (PL) stage shrimp. By comparing shrimp infected with VPAHPND, those infected with non-VPAHPND, and uninfected shrimp (controls), we identified different VPAHPND infection responses, including significant cytoskeleton and metabolic reprogramming changes. Specifically, VPAHPND infection disturbed lipid, glutathione, and bile acid metabolism, while a key regulatory factor Farnesoid X Receptor (FXR) in these pathways was down-regulated. These findings suggest that VPAHPND manipulates host metabolism to enhance infectivity, leading to severe and irreparable hepatopancreas damage. Our study highlights the molecular interactions between VPAHPND and shrimp, and provides potential targets to mitigate the impact of AHPND in aquaculture.
WOS关键词NECROSIS DISEASE AHPND ; VIBRIO-PARAHAEMOLYTICUS ; SHRIMP HEMOCYTES ; CULTURED SHRIMP ; CAUSATIVE AGENT ; HOST RESPONSE
资助项目National Natural Science Foundation of China[42476114] ; Shandong Provincial Natural Science Foundation[ZR2023MC096] ; Key R&D Project of Shandong Province[2023TZXD047]
WOS研究方向Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种英语
WOS记录号WOS:001325239400001
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
源URL[http://ir.qdio.ac.cn/handle/337002/199228]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Liu, Mei; Wang, Lei
作者单位1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
2.Chinese Acad Sci, Qingdao, Peoples R China
3.Marine Sci Res Inst Shandong Prov, Shandong Key Lab Dis Control Mariculture, Qingdao, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhao, Zhen,Wang, Baojie,Jiang, Keyong,et al. Comparative analysis of transcriptomics and metabolomics provides insights into the mechanisms of VP AHPND invasion and hepatopancreatic damage in Litopenaeus vannamei[J]. FISH & SHELLFISH IMMUNOLOGY,2024,154:13.
APA Zhao, Zhen,Wang, Baojie,Jiang, Keyong,Liu, Mei,&Wang, Lei.(2024).Comparative analysis of transcriptomics and metabolomics provides insights into the mechanisms of VP AHPND invasion and hepatopancreatic damage in Litopenaeus vannamei.FISH & SHELLFISH IMMUNOLOGY,154,13.
MLA Zhao, Zhen,et al."Comparative analysis of transcriptomics and metabolomics provides insights into the mechanisms of VP AHPND invasion and hepatopancreatic damage in Litopenaeus vannamei".FISH & SHELLFISH IMMUNOLOGY 154(2024):13.

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来源：海洋研究所

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