The Evolution and Biological Activity of Metazoan Mixed Lineage Kinase Domain-Like Protein (MLKL)
文献类型：期刊论文
| 作者 | Wang, Qingyue1,2,3; Yuan, Zihao1,2 ; Xu, Hang1,2; Chen, Yuan1,2,3; Sun, Li1,2,3
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| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| 出版日期 | 2024-10-01 |
| 卷号 | 25期号:19页码:12 |
| 关键词 | MLKL necroptosis evolution |
| ISSN号 | 1661-6596 |
| DOI | 10.3390/ijms251910626 |
| 通讯作者 | Yuan, Zihao(yuanzihao@qdio.ac.cn) ; Sun, Li(lsun@qdio.ac.cn) |
| 英文摘要 | In mammals, mixed lineage kinase domain-like protein (MLKL) is the executor of necroptosis. MLKL comprises an N-terminal domain (NTD), which alone suffices to trigger necroptosis by forming pores in the plasma membrane, and a C-terminal domain that inhibits the NTD activity. Evolutionarily, MLKL is poorly conserved in animals and not found in Protostomia. Although MLKL orthologs exist in invertebrate Deuterostomia, the biological activity of invertebrate MLKL is unknown. Herein, we examined 34 metazoan phyla and detected MLKL not only in Deuterostomia but also in Protostomia (Rotifera). The Rotifera MLKL exhibited low identities with non-Rotifera MLKL but shared relatively high identities with non-metazoan MLKL. In invertebrates, MLKL formed two phylogenetic clades, one of which was represented by Rotifera. In vertebrates, MLKL expression was tissue-specific and generally rich in immune organs. When expressed in human cells, the MLKL-NTD of Rotifera, Echinodermata, Urochordata, and Cephalochordata induced strong necroptosis. The necroptotic activity of Rotifera MLKL depended on a number of conserved residues. Together these findings provided new insights into the evolution of MLKL in Metazoa and revealed the biological activity of invertebrate MLKL. |
| WOS关键词 | PROGRAMMED NECROSIS ; NECROPTOSIS ; INFLAMMATION ; RIP3 ; DOWNSTREAM ; DIVERGENCE ; ACTIVATION ; BINDING ; FAMILY |
| 资助项目 | Science & Technology Innovation Project of Laoshan Laboratory ; Science Fund Program for Distinguished Young Scholars of Shandong Province (Overseas)[2022HWYQ-087] ; Innovation Research Group Project of the National Natural Science Foundation of China[42221005] ; Chinese Academy of Sciences ; [LSKJ202203000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001332405200001 |
| 出版者 | MDPI |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/199291]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Yuan, Zihao; Sun, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266404, Peoples R China 2.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Coll Marine Sci, Qingdao 266404, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qingyue,Yuan, Zihao,Xu, Hang,et al. The Evolution and Biological Activity of Metazoan Mixed Lineage Kinase Domain-Like Protein (MLKL)[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2024,25(19):12. |
| APA | Wang, Qingyue,Yuan, Zihao,Xu, Hang,Chen, Yuan,&Sun, Li.(2024).The Evolution and Biological Activity of Metazoan Mixed Lineage Kinase Domain-Like Protein (MLKL).INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,25(19),12. |
| MLA | Wang, Qingyue,et al."The Evolution and Biological Activity of Metazoan Mixed Lineage Kinase Domain-Like Protein (MLKL)".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25.19(2024):12. |
入库方式： OAI收割
来源：海洋研究所
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