Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo
文献类型：期刊论文
| 作者 | Jiang, Tao3 ; Zhu, Feikai3; Gao, Xintao3; Wu, Xiaochen3; Zhu, Wenyong1; Guo, Chuanlong2,3
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| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
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| 出版日期 | 2025 |
| 卷号 | 245页码:10 |
| 关键词 | Acute kidney injury Folic acid Naringenin CGAS-STING |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2024.114343 |
| 通讯作者 | Zhu, Wenyong(zwy2023ql@126.com) ; Guo, Chuanlong(guochuanlong@qust.edu.cn) |
| 英文摘要 | Acute kidney injury (AKI) is a common clinical problem with no effective treatment. Excessive folic acid (FA) induced kidney tubular injury is characterized by oxidative stress and inflammation, and is a common model of AKI. The excellent pharmacological activity of naringenin (NAR) makes it a potential agent for treating AKI, but its poor solubility limits its application. This study prepared NAR loaded nanoparticles (FU/PVP-NAR) using fucoidan (FU) and polyvinylpyrrolidone (PVP) as carriers, with a particle size of 23.96 +/- 2.77 nm. In vitro studies showed that FU/PVP-NAR inhibited excessive FA induced proliferation inhibition, accumulation of reactive oxygen species (ROS), and disruption of mitochondrial membrane potential (MMP) of HK-2 cells. Further confirmed that FU/PVP-NAR inhibited FA induced DNA damage and Cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) activation. In vivo studies showed that excessive FA induced AKI features in mice, such as elevated serum creatinine (SCr) and blood urea nitrogen (BUN) levels, accompanied by pathological damage to kidney tissues. The above AKI characteristics induced by FA were alleviated by FU/PVP-NAR. FU/PVP-NAR also inhibited the decrease in antioxidant enzyme levels in kidney tissues induced by FA. Furthermore, in vivo mechanism studies indicated that FU/PVP-NAR inhibited the release of inflammatory factors by inhibiting DNA damage-cGAS-STING pathway. In summary, this study provided the possibility for FU/PVPNAR as a potential candidate drug for treating FA induced AKI. |
| WOS关键词 | DNA-DAMAGE ; INFLAMMATION ; NEPHROTOXICITY ; CONSEQUENCES ; ACTIVATION |
| 资助项目 | National Natural Science Foundation of China[22307060] ; Shandong Provincial Natural Science Foundation[ZR2020QH359] ; Open Fund of CAS ; Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences[KF2022NO06] |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001349575300001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/199390]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Zhu, Wenyong; Guo, Chuanlong |
| 作者单位 | 1.Shandong Univ, Qilu Hosp Qingdao, Cheeloo Coll Med, Dept Thorac Surg, Qingdao 266035, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Tao,Zhu, Feikai,Gao, Xintao,et al. Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2025,245:10. |
| APA | Jiang, Tao,Zhu, Feikai,Gao, Xintao,Wu, Xiaochen,Zhu, Wenyong,&Guo, Chuanlong.(2025).Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo.COLLOIDS AND SURFACES B-BIOINTERFACES,245,10. |
| MLA | Jiang, Tao,et al."Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo".COLLOIDS AND SURFACES B-BIOINTERFACES 245(2025):10. |
入库方式： OAI收割
来源：海洋研究所
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