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Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters

文献类型：期刊论文

作者Wang, Chaogang2,4,5; Jiang, Zhuxiang2,5,6; Du, Mingyang2,5,6; Cong, Rihao1,2,5,8; Wang, Wei2,3,5; Zhang, Taiping2,5,6; Chen, Jincheng2,5,6; Zhang, Guofan1,2,4,5,7,8; Li, Li2,3,4,5,6,7
刊名CELL COMMUNICATION AND SIGNALING
出版日期2024-11-11
卷号22期号:1页码:27
关键词NF-kappa B pathway MAPK pathway I kappa B alpha ERK Temperature Adaptation Oysters
DOI10.1186/s12964-024-01923-0
通讯作者Li, Li(lili@qdio.ac.cn)
英文摘要Phosphorylation of Ser32 and Ser36 controls the degradation of I kappa B alpha is the conserved cascade mechanisms of immune core signaling pathway, NF-kappa B pathway in metazoans, but it's response to abiotic stress and the presence of novel phosphorylation mechanisms in other species remain unclear. Herein, we reported a novel heat-induced phosphorylation site (Ser74) at oysters' major I kappa B alpha, which independently regulated ubiquitination-proteasome degradation without the requirement of phosphorylation at S32 and S36. And this site was phosphorylated by ERK/MAPK pathway, which then promoted REL nuclear translocation to activate cell survival related genes to defend heat-stress. The MAPK-NF-kappa B cascade exhibited divergent thermal responses and adaptation patterns between two congeneric oyster species with differential habitat temperatures, indicating its involvement in shaping temperature adaptation. This study demonstrated that the existence of complex and unique phosphorylation-mediated signaling transduction mechanism in marine invertebrates, and expanded our understanding of the evolution and function of established classical pathway crosstalk mechanisms.
WOS关键词NATIVE MYTILUS-CALIFORNIANUS ; ACTIVATED PROTEIN-KINASE ; MOLECULAR CHARACTERIZATION ; SIGNALING PATHWAY ; OXIDATIVE STRESS ; HEAT-SHOCK ; EXPRESSION ; GALLOPROVINCIALIS ; GENES ; ERK
资助项目National Key R&D Program of China[2022YFD2400304] ; Key Research and Development Program of Shandong[2022LZGC015] ; Key Research and Development Program of Shandong[ZFJH202309] ; China Agriculture Research System of MOF[CARS-49]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:001352447400002
出版者BMC
源URL[http://ir.qdio.ac.cn/handle/337002/199423]  
专题海洋研究所_实验海洋生物学重点实验室
通讯作者Li, Li
作者单位1.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China
3.Qingdao Marine Sci & Technol Ctr, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Key Lab Breeding Biotechnol & Sustainable Aquacult, Qingdao, Peoples R China
5.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Shandong Technol Innovat Ctr Oyster Seed Ind, Qingdao, Peoples R China
8.Southern Marine Sci & Engn Guangdong Lab Zhanjiang, Zhanjiang, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Chaogang,Jiang, Zhuxiang,Du, Mingyang,et al. Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters[J]. CELL COMMUNICATION AND SIGNALING,2024,22(1):27.
APA Wang, Chaogang.,Jiang, Zhuxiang.,Du, Mingyang.,Cong, Rihao.,Wang, Wei.,...&Li, Li.(2024).Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters.CELL COMMUNICATION AND SIGNALING,22(1),27.
MLA Wang, Chaogang,et al."Novel Ser74 of NF-κB/IκBα phosphorylated by MAPK/ERK regulates temperature adaptation in oysters".CELL COMMUNICATION AND SIGNALING 22.1(2024):27.

入库方式： OAI收割

来源：海洋研究所

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