Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus Aplosporella javeedii using OSMAC strategy
文献类型：期刊论文
| 作者 | Gao, Ying1,9; Frank, Marian1; Teusch, Nicole1; Woschko, Dennis2; Janiak, Christoph2; Mandi, Attila3; Kurtan, Tibor3; Hartmann, Rudolf4; Schiedlauske, Katja1; van Geelen, Lasse1 |
| 刊名 | FRONTIERS IN MICROBIOLOGY
 |
| 出版日期 | 2024-09-27 |
| 卷号 | 15页码:10 |
| 关键词 | Aplosporella javeedii alkaloids OSMAC approach X-ray diffraction DFT-NMR calculations TDDFT-ECD calculations target prediction |
| DOI | 10.3389/fmicb.2024.1458622 |
| 通讯作者 | Proksch, Peter(proksch@uni-duesseldorf.de) ; Liu, Zhen(liuzhen2020@hunnu.edu.cn) |
| 英文摘要 | Three sulfur-containing alkaloids aplospojaveedins A-C (1-3) with a hitherto undescribed carbon skeleton comprising octahy-dronaphthalene, alpha, beta-unsaturated lactam and glycine-cysteine moieties were isolated from Aplosporella javeedii. Their structures were elucidated by 1D and 2D NMR spectroscopy, HR-MS, X-ray diffraction analysis, DFT-NMR and TDDFT-ECD calculations. A plausible biosynthetic pathway and putative targets are described. The blind docking suggested that 1-3 may have functional effects on several putative targets such as the GPCR cannabinoid receptor 2 or the integrin alpha 5 beta 1 complex. |
| WOS关键词 | CRYSTAL-STRUCTURE ; ACTIVATION ; DOCKING ; IDENTIFICATION ; INHIBITORS ; EQUISETIN ; BINDING |
| 资助项目 | Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)[INST 208/589-1] ; National Research Development and Innovation Office[K-138672] ; National Research Development and Innovation Office[FK-134653] ; Deutsche Forschungsgemeinschaft [DFG, German Research Foundation][270650915/GRK 2158] ; Hunan Provincial Natural Science Foundation of China[2022JJ40286] ; Changsha Municipal Natural Science Foundation[kq2202257] ; Intra Institutional Open Fund of School of Medicine, Hunan Normal University[KF2022001] |
| WOS研究方向 | Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:001336664800001 |
| 出版者 | FRONTIERS MEDIA SA |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/199498]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Proksch, Peter; Liu, Zhen |
| 作者单位 | 1.Heinrich Heine Univ, Inst Pharmaceut Biol & Biotechnol, Dusseldorf, Germany 2.Heinrich Heine Univ, Inst Inorgan & Struct Chem, Dusseldorf, Germany 3.Univ Debrecen, Dept Organ Chem, Debrecen, Hungary 4.Forschungszentrum Julich, Inst Biol Informat Proc Struct Biochem IBI 7, Julich, Germany 5.Heinrich Heine Univ, Inst Pharmaceut & Med Chem, Dusseldorf, Germany 6.Forschungszentrum Julich, Inst Bioand Geosci IBG 4 Bioinformat, Julich, Germany 7.Chinese Acad Sci, Inst Oceanol, CAS, Qingdao, Peoples R China 8.Chinese Acad Sci, Inst Oceanol, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 9.Hunan Normal Univ, Sch Med, Key Lab Study & Discovery Small Targeted Mol Hunan, Changsha, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Ying,Frank, Marian,Teusch, Nicole,et al. Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus Aplosporella javeedii using OSMAC strategy[J]. FRONTIERS IN MICROBIOLOGY,2024,15:10. |
| APA | Gao, Ying.,Frank, Marian.,Teusch, Nicole.,Woschko, Dennis.,Janiak, Christoph.,...&Liu, Zhen.(2024).Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus Aplosporella javeedii using OSMAC strategy.FRONTIERS IN MICROBIOLOGY,15,10. |
| MLA | Gao, Ying,et al."Aplospojaveedins A-C, unusual sulfur-containing alkaloids produced by the endophytic fungus Aplosporella javeedii using OSMAC strategy".FRONTIERS IN MICROBIOLOGY 15(2024):10. |
入库方式： OAI收割
来源：海洋研究所
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