Zn2+enhanced the anti-breast cancer activity of fucoidan based nanoparticles by activating the cGAS-STING pathway
文献类型：期刊论文
| 作者 | Xue, Pengyu3; Wang, Yinghan3; Wang, Xuefei3; Zhou, Shilin3; Wu, Xiaochen3; Long, Lin2; Guo, Chuanlong1,3 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2024-11-15 |
| 卷号 | 500页码:13 |
| 关键词 | Breast Fucoidan Resveratrol cGAS-STING Zn 2+ |
| ISSN号 | 1385-8947 |
| DOI | 10.1016/j.cej.2024.156729 |
| 通讯作者 | Long, Lin(longlin89@126.com) ; Guo, Chuanlong(guochuanlong@qust.edu.cn) |
| 英文摘要 | The incidence rate of breast cancer remains high, and lung metastasis often leads to treatment failure. Immunotherapy based on the cyclic guanosine monophosphate synthesis (cGAS) - interface gene stimulatory factor (STING) pathway is expected to bring benefits to the treatment of breast cancer. This study provided a delivery system based on fucoidan (Fu) and polyvinylpyrrolidone (PVP) for the potential molecule resveratrol (Res). The study confirmed that Fu and PVP were assembled into nanoparticles through hydrogen bonding and effectively loaded Res (Fu/PVP/Res). Interestingly, the adsorption of Zn2+ (Fu/PVP/Res Zn2+) was expected to provide impetus for the treatment of breast cancer. The results in vitro confirmed that Fu/PVP/Res Zn2+ significantly inhibited the proliferation of breast cancer 4T1 cells, induced the accumulation of mitochondrial reactive oxygen species (ROS) and the damage of mitochondrial membrane potential (MMP), and further induced the cytoplasmic release of mtDNA, which was the direct cause of the activation of cGAS-STING pathway. In vivo studies confirmed that Fu/PVP/Res Zn2+ treatment inhibited the growth of 4T1 transplanted tumors. Excitingly, Fu/PVP/Res Zn2+ treatment also prevented lung metastasis of in situ tumors. The in vivo mechanism confirmed that Fu/PVP/Res Zn2+ treatment activated the cGAS-STING pathway and induced abnormal expression of tumor apoptosis factors such as Bax/Bcl-2. In conclusion, our research provided potential for the treatment of breast cancer. |
| WOS关键词 | SOLID LIPID NANOPARTICLES ; RESVERATROL ; 2ND-MESSENGER ; CHEMOTHERAPY |
| 资助项目 | National Natural Science Foundation of China[22307060] ; Shandong Provincial Natural Science Foundation[ZR2020QH359] ; Open Fund of CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences[KF2022NO06] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001342708500001 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/199528]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Long, Lin; Guo, Chuanlong |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Univ, Qingdao Tradit Chinese Med Hosp, Oncol Ctr Dept 1, Qingdao Hiser Hosp, Qingdao 266033, Peoples R China 3.Qingdao Univ Sci & Technol, Coll Chem Engn, Qingdao 266042, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Pengyu,Wang, Yinghan,Wang, Xuefei,et al. Zn2+enhanced the anti-breast cancer activity of fucoidan based nanoparticles by activating the cGAS-STING pathway[J]. CHEMICAL ENGINEERING JOURNAL,2024,500:13. |
| APA | Xue, Pengyu.,Wang, Yinghan.,Wang, Xuefei.,Zhou, Shilin.,Wu, Xiaochen.,...&Guo, Chuanlong.(2024).Zn2+enhanced the anti-breast cancer activity of fucoidan based nanoparticles by activating the cGAS-STING pathway.CHEMICAL ENGINEERING JOURNAL,500,13. |
| MLA | Xue, Pengyu,et al."Zn2+enhanced the anti-breast cancer activity of fucoidan based nanoparticles by activating the cGAS-STING pathway".CHEMICAL ENGINEERING JOURNAL 500(2024):13. |
入库方式： OAI收割
来源：海洋研究所
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