Growth and reproductive toxicity of bisphenol A in Oikopleura dioica at environmentally relevant concentrations
文献类型：期刊论文
| 作者 | Li, Shuai1; Liang, Yi4 ; Zhang, Guangtao1,2,3
|
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2024-11-05 |
| 卷号 | 479页码:13 |
| 关键词 | Bisphenol A Toxicological response Environmentally safe concentration Transcriptomics Marine appendicularians |
| ISSN号 | 0304-3894 |
| DOI | 10.1016/j.jhazmat.2024.135552 |
| 通讯作者 | Zhang, Guangtao(gtzhang@qdio.ac.cn) |
| 英文摘要 | Bisphenol A (BPA), a known endocrine disruptor, is ubiquitous in various aquatic environments. Appendicularians are among the most abundant mesozooplankton populations and occupy a crucial niche in marine ecosystems. However, no toxicological data are available concerning the effects of BPA on this functional group. In this study, an evaluation of the toxicity of environmentally relevant levels of BPA (2.5-150 mu g/L) on the appendicularian Oikopleura dioica, including its morphology and transcriptome, was conducted. Our results demonstrated the high sensitivity of O. dioica to BPA, with a LC50 of 142 mu g/L. Exposure to 125 mu g/L BPA significantly inhibited the somatic growth, gonadal development and reproduction of individuals, whereas exposure to an environmentally safe concentration (2.5 mu g/L) affected female fecundity and fitness as well as male gene expression. The results of the transcriptomic analysis suggest that males were more sensitive to BPA stress at the molecular level. BPA exposure not only led to abnormal secretion of digestive enzymes and phospholipase A2, affecting the function of the digestive system and arachidonic acid but also significantly downregulated the expression of mRNAs related to enzymes involved in carbohydrate and energy metabolism in males. These findings suggest that the current safe environmental concentrations may not be safe. |
| WOS关键词 | ENDOCRINE DISRUPTORS ; APPENDICULARIAN ; IDENTIFICATION ; QUALITY ; MODEL ; CYCLE ; BPA |
| 资助项目 | National Natural Science Foundation of China[42306153] ; Shandong Provincial Natural Science Foundation[ZR2020QC043] |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001304539700001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/198191]  |
| 专题 | 海洋研究所_海洋生态与环境科学重点实验室 |
| 通讯作者 | Zhang, Guangtao |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Jiaozhou Bay Natl Marine Ecosyst Res Stn, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Shuai,Liang, Yi,Zhang, Guangtao. Growth and reproductive toxicity of bisphenol A in Oikopleura dioica at environmentally relevant concentrations[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,479:13. |
| APA | Li, Shuai,Liang, Yi,&Zhang, Guangtao.(2024).Growth and reproductive toxicity of bisphenol A in Oikopleura dioica at environmentally relevant concentrations.JOURNAL OF HAZARDOUS MATERIALS,479,13. |
| MLA | Li, Shuai,et al."Growth and reproductive toxicity of bisphenol A in Oikopleura dioica at environmentally relevant concentrations".JOURNAL OF HAZARDOUS MATERIALS 479(2024):13. |
入库方式： OAI收割
来源：海洋研究所
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