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Acquisition and evolution of the neurotoxin domoic acid biosynthesis gene cluster in Pseudo-nitzschia species

文献类型：期刊论文

作者He, Ziyan1,2,3,4; Xu, Qing1,2,4,5; Chen, Yang1,2,3,4; Liu, Shuya1,2,4; Song, Huiyin1,2,4; Wang, Hui1,2,4; Leaw, Chui Pin6; Chen, Nansheng1,2,4
刊名COMMUNICATIONS BIOLOGY
出版日期2024-10-23
卷号7期号:1页码:12
DOI10.1038/s42003-024-07068-7
通讯作者Chen, Nansheng(chenn@qdio.ac.cn)
英文摘要Of the hitherto over 60 taxonomically identified species in the genus of Pseudo-nitzschia, 26 have been confirmed to be toxigenic. Nevertheless, the acquisition and evolution of the toxin biosynthesis (dab) genes by this extensive group of Pseudo-nitzschia species remains unclear. Through constructing chromosome-level genomes of three Pseudo-nitzschia species and draft genomes of ten additional Pseudo-nitzschia species, putative genomic integration sites for the dab genes in Pseudo-nitzschia species were explored. A putative breakpoint was observed in syntenic regions in the dab gene cluster-lacking Pseudo-nitzschia species, suggesting potential independent losses of dab genes. The breakpoints between this pair of conserved genes were also identified in some dab genes-possessing Pseudo-nitzschia species, suggesting that the dab gene clusters transposed to other loci after the initial integration. A "single acquisition, multiple independent losses (SAMIL)" model is proposed to explain the acquisition and evolution of the dab gene cluster in Pseudo-nitzschia species. A "single acquisition, multiple independent losses (SAMIL)" model is proposed to explain the acquisition and evolution of the domoic acid biosynthesis gene cluster in Pseudo-nitzschia species.
WOS关键词MULTIPLE SEQUENCE ALIGNMENT ; MITOCHONDRIAL GENOME ; BACILLARIOPHYCEAE ; TOOL ; IDENTIFICATION ; DOMAINS ; PREDICTION ; SHELLFISH ; ALGORITHM ; TOXICITY
资助项目Strategic Priority Research Program of Chinese Academy of Sciences (XDB42000000)[XDB42000000] ; Strategic Priority Research Program of Chinese Academy of Sciences ; Chinese Academy of Sciences Pioneer Hundred Talents Program ; Taishan Scholar Project Special Fund[19-3-2-16-zhc] ; Qingdao Innovation and Creation Plan (Talent Development Program - 5th Annual Pioneer and Innovator Leadership Award) ; Natural Sciences and Engineering Research Council of Canada (NSERC)
WOS研究方向Life Sciences & Biomedicine - Other Topics ; Science & Technology - Other Topics
语种英语
WOS记录号WOS:001339872600001
出版者NATURE PORTFOLIO
源URL[http://ir.qdio.ac.cn/handle/337002/199558]  
专题海洋研究所_海洋生态与环境科学重点实验室
通讯作者Chen, Nansheng
作者单位1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266200, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Coll Marine Sci, Beijing 10039, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
5.China Three Gorges Univ, Coll Basic Med Sci, Hubei Key Lab Tumor Microenvironm & Immunotherapy, Yichang 443002, Peoples R China
6.Univ Malaya, Inst Ocean & Earth Sci, Bachok Marine Res Stn, Bachok 16310, Kelantan, Malaysia
推荐引用方式
GB/T 7714		 He, Ziyan,Xu, Qing,Chen, Yang,et al. Acquisition and evolution of the neurotoxin domoic acid biosynthesis gene cluster in Pseudo-nitzschia species[J]. COMMUNICATIONS BIOLOGY,2024,7(1):12.
APA He, Ziyan.,Xu, Qing.,Chen, Yang.,Liu, Shuya.,Song, Huiyin.,...&Chen, Nansheng.(2024).Acquisition and evolution of the neurotoxin domoic acid biosynthesis gene cluster in Pseudo-nitzschia species.COMMUNICATIONS BIOLOGY,7(1),12.
MLA He, Ziyan,et al."Acquisition and evolution of the neurotoxin domoic acid biosynthesis gene cluster in Pseudo-nitzschia species".COMMUNICATIONS BIOLOGY 7.1(2024):12.

入库方式： OAI收割

来源：海洋研究所

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