Two novel antimicrobial peptides P 33-57 and mP 168-187 from zebrafish showing potent antibacterial activities
文献类型：期刊论文
| 作者 | Guo, Dongqiu1; Wang, Hao1,2; He, Jing1; Zhang, Liqiao1; Liu, Longxiao1; Wang, Xia1
|
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2024-11-01 |
| 卷号 | 154页码:10 |
| 关键词 | Plekhf2 PH domain FYVE domain Candidate peptides Antibacterial activities |
| ISSN号 | 1050-4648 |
| DOI | 10.1016/j.fsi.2024.109950 |
| 通讯作者 | Wang, Xia(wxbiology@qust.edu.cn) |
| 英文摘要 | It is known that overuse or abuse of antibiotics has undoubtedly accelerated the global antibiotic resistance crisis, and long-time use of antibiotics may have adverse effects on the health of animal, human, and ecosystem. Therefore, it is necessary to find antibiotic alternatives that can be used in aquaculture and are non-toxic to the human. Here we clearly demonstrated that both the PH and FYVE domain of Plekhf2 in zebrafish have antibacterial properties and can interact with PGN in this study. Therefore, we screened four candidate peptides from the two domains. It was demonstrated that P 152-172 and P 168-187 had no obvious antibacterial activities, while P 33- 57 and mP 168-187 had strong antibacterial activities, which may be used as antimicrobial peptides. Additionally, transmission electron microscopy experiment revealed that P 33-57 and mP 168-187 can destroy the cell wall of bacteria, thereby directly killing bacteria. Importantly, it was found that P 33-57 and mP 168-187 had no hemolysis to red blood cells and lacked cytotoxicity. In summary, P 33-57 and mP 168-187 could be seen as antibacterial activity centers of PLEKHF2 and may be promising antimicrobial peptides to combat bacterial infections facing an antibiotic-resistance crisis. |
| 资助项目 | National Natural Science Foundation |
| WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001338834600001 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/199549]  |
| 专题 | 海洋研究所_海洋生物分类与系统演化实验室 |
| 通讯作者 | Wang, Xia |
| 作者单位 | 1.Qingdao Univ Sci & Technol, Coll Marine Sci & Biol Engn, Shandong Prov Key Lab Biochem Engn, Qingdao 266042, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Lab Marine Organism Taxon & Phylogeny, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Dongqiu,Wang, Hao,He, Jing,et al. Two novel antimicrobial peptides P 33-57 and mP 168-187 from zebrafish showing potent antibacterial activities[J]. FISH & SHELLFISH IMMUNOLOGY,2024,154:10. |
| APA | Guo, Dongqiu,Wang, Hao,He, Jing,Zhang, Liqiao,Liu, Longxiao,&Wang, Xia.(2024).Two novel antimicrobial peptides P 33-57 and mP 168-187 from zebrafish showing potent antibacterial activities.FISH & SHELLFISH IMMUNOLOGY,154,10. |
| MLA | Guo, Dongqiu,et al."Two novel antimicrobial peptides P 33-57 and mP 168-187 from zebrafish showing potent antibacterial activities".FISH & SHELLFISH IMMUNOLOGY 154(2024):10. |
入库方式： OAI收割
来源：海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。