Inhibition of bacteria adhesion and biofilm formation using a precisely structured nitric oxide-releasing coating with repeatedly renewing antimicrobial and antifouling ability
文献类型：期刊论文
| 作者 | Zhao, Haibin1,2,3; Sun, Yihan2; Shen, Yuanyuan2; Tan, Ming3; Wang, Peng2
|
| 刊名 | APPLIED MATERIALS TODAY
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 41页码:8 |
| 关键词 | Antifouling Biofilm Nitric oxide Surface modification |
| ISSN号 | 2352-9407 |
| DOI | 10.1016/j.apmt.2024.102468 |
| 通讯作者 | Tan, Ming(tanming@qust.edu.cn) ; Wang, Peng(wangpeng@qdio.ac.cn) |
| 英文摘要 | Bacterial adhesion and colonization usually causes the formation of biofilm that cannot be easily eradicated by common antibiotics and disinfectants. Surface covalent immobilization of nitric oxide (NO)-releasing polymer is an effective surface modification strategy to combat the threat from bacteria. Although surface covalent strategy avoided the leaching of toxic NO donors, the existence of hydrophobic NO donors on topsurface could inevitably accelerate the microorganism adhesion and accumulation, and the NO-releasing period of time was still very limited. In this work, we prepared an antimicrobial and antibiofilm surface via tethering a precision-structured NO-releasing copolymer brush to an organic-inorganic hybrid hard coating (> 5H pencil hardness) on one end. The precision-structured diblock copolymer brush was composed of a surface antifouling block and a subsurface antimicrobial block of NO-releasing units. A typical effect of "kill two birds with one stone" was observed, the NO releasing subsurface segment within a polymeric matrix prolongs NO release while also preventing surface fouling caused by hydrophobic NO donors on top surface. The impacts of polymer architecture on bioactivity was detailed investigated, and the block copolymer brush exhibited the optimal inhibitory effects against bacteria colonization and biofilm formation. The developed bioactive diblock copolymer brush was grafted from a hard hybrid persistent coating that embeds considerable initiation sites for surface modification. Thanks to the presence of initiator throughout the hybrid network, the initiation layer could initiate polymerization repeatedly after the polymer brushes are worn off at high pressure. Thus, the coating exhibited repeatedly renewing antimicrobial and antifouling ability after multiple abrasion cycles. This work not only developed a novel strategy for regulating NO releasing via modulating the polymer architecture, but provided a feasible route for obtaining a robust initiator layer for synthesizing polymer brush for antimicrobial and antifouling applications. |
| WOS关键词 | SILVER NANOPARTICLES ; POLYMER ; ANTIBACTERIAL ; ANTIBIOTICS ; RESISTANCE ; SURFACES ; STRATEGY ; DONOR ; NO |
| 资助项目 | National Natural Science Foundation of China[52205227] ; National Natural Science Foundation of China[U22A20112] ; Nantong Scientific Plan Foundation[JC12022099] ; Guangxi Natural Science Foundation[2023GXNSFDA026059] |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001334197800001 |
| 出版者 | ELSEVIER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/199333]  |
| 专题 | 海洋研究所_海洋腐蚀与防护研究发展中心 |
| 通讯作者 | Tan, Ming; Wang, Peng |
| 作者单位 | 1.Guangxi Acad Sci, Guangxi Acad Marine Sci, Inst Marine Corros Protect, Guangxi Key Lab Marine Environm Sci, Nanning 530007, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Adv Marine Mat, Key Lab Marine Environm Corros & Biofouling, Qingdao 266071, Peoples R China 3.Qingdao Univ Sci & Technol, Coll Environm & Safety Engn, Qingdao 266042, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Haibin,Sun, Yihan,Shen, Yuanyuan,et al. Inhibition of bacteria adhesion and biofilm formation using a precisely structured nitric oxide-releasing coating with repeatedly renewing antimicrobial and antifouling ability[J]. APPLIED MATERIALS TODAY,2024,41:8. |
| APA | Zhao, Haibin,Sun, Yihan,Shen, Yuanyuan,Tan, Ming,&Wang, Peng.(2024).Inhibition of bacteria adhesion and biofilm formation using a precisely structured nitric oxide-releasing coating with repeatedly renewing antimicrobial and antifouling ability.APPLIED MATERIALS TODAY,41,8. |
| MLA | Zhao, Haibin,et al."Inhibition of bacteria adhesion and biofilm formation using a precisely structured nitric oxide-releasing coating with repeatedly renewing antimicrobial and antifouling ability".APPLIED MATERIALS TODAY 41(2024):8. |
入库方式： OAI收割
来源：海洋研究所
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