Strap-on Buoyant Device to Enhance Gastrointestinal Tract Retention of Felodipine Osmotic Pump Tablets
文献类型：期刊论文
| 作者 | Ni, Qijia5,7; Li, Zeru6; Baqing, Libumo5,7; Li, Tianfu2,5; Xu, Huipeng8; Li, Falan5,7; Peng, Ningning2,5; Wang, Caifen8; Lu, Jianhua1; Wang, Zhigang1 |
| 刊名 | AAPS PHARMSCITECH
 |
| 出版日期 | 2024-11-01 |
| 卷号 | 25期号:8页码:14 |
| 关键词 | Gastro-retentive floating device Osmotic pump Pharmacokinetic Stereolithography three-dimensional printing |
| ISSN号 | 1530-9932 |
| DOI | 10.1208/s12249-024-02976-7 |
| 通讯作者 | Yang, Ye(Y.Yang@ahtcm.edu.cn) ; Zhou, Hua(zh@lifeon.cn) ; Gu, Yongdong(ydgu@innostar.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | Osmotic pump systems require prolonged retention time in the stomach to provide enhanced bioavailability and regulated release, which is quite challenging. This study used a three-dimensional printing (3DP) technique combined with a gastro-retentive floating device (GRFD) to extend the retention of the osmotic pump in the stomach and enhance its bioavailability. The strap-on buoyant device was fabricated by stereolithography 3DP and incorporated a felodipine osmotic pump tablet used in clinical practice, which enabled it to float in the stomach or dissolution media without any floating lag time. The components of the device were affixed using a snap-fix mechanism. GRFD dissolution study revealed a notable in vitro floating capability, lasting over 24 h, with a release profile similarity factor f2 = 65.28 compared to the naked tablet dissolution profile. The pharmacokinetics of felodipine osmotic pump in beagles showed a Cmax of 1.893 ng/mL, which increased to 4.511 ng/mL with GRFD. The delivery of an osmotic pump with GRFD enhanced the AUC0-infinity of felodipine from 10.20 ng/mL |
| WOS关键词 | DRUG-DELIVERY SYSTEMS ; SIMILARITY FACTOR ; FLOATING TABLETS ; RELEASE ; DESIGN ; TIME |
| 资助项目 | National Natural Science Foundation of China[82273863] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001345941600001 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314291]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yang, Ye; Zhou, Hua; Gu, Yongdong; Zhang, Jiwen |
| 作者单位 | 1.Nantong Haimen Peoples Hosp, Nantong 226199, Peoples R China 2.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China 3.Hefei Lifeon Pharmaceut Co Ltd, Hefei 230088, Peoples R China 4.InnoStar Biotech Nantong Co Ltd, Nantong 226133, Peoples R China 5.Yangtze Delta Drug Adv Res Inst, Nantong 226133, Peoples R China 6.Nanjing Univ Chinese Med, Nanjing 210023, Peoples R China 7.Anhui Univ Chinese Med, Hefei 230000, Peoples R China 8.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ni, Qijia,Li, Zeru,Baqing, Libumo,et al. Strap-on Buoyant Device to Enhance Gastrointestinal Tract Retention of Felodipine Osmotic Pump Tablets[J]. AAPS PHARMSCITECH,2024,25(8):14. |
| APA | Ni, Qijia.,Li, Zeru.,Baqing, Libumo.,Li, Tianfu.,Xu, Huipeng.,...&Zhang, Jiwen.(2024).Strap-on Buoyant Device to Enhance Gastrointestinal Tract Retention of Felodipine Osmotic Pump Tablets.AAPS PHARMSCITECH,25(8),14. |
| MLA | Ni, Qijia,et al."Strap-on Buoyant Device to Enhance Gastrointestinal Tract Retention of Felodipine Osmotic Pump Tablets".AAPS PHARMSCITECH 25.8(2024):14. |
入库方式： OAI收割
来源：上海药物研究所
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