Solvent-Controlled Divergent Cyclization of 3-Ylideneoxindoles with Ethyl 2-Diazoacetate: Access to Spirocyclopropyl and Spiropyrazolines Oxindoles
文献类型：期刊论文
| 作者 | Xie, Ding-Xiong3; Huang, Yue-Mei3; Lin, Xiao-Ming3; Kang, Zheng-Hui1; Ni, Chen-Chen3; Fu, Yao-Tong3; Ren, Zhi4; Liu, Yun-Lin2,3 |
| 刊名 | CHEMISTRY-A EUROPEAN JOURNAL
 |
| 出版日期 | 2024-10-29 |
| 页码 | 7 |
| 关键词 | Spirocyclopropyl oxindole Spiropyrazoline oxindole Catalyst-free Solvent-controlled 3-Ylideneoxindole |
| ISSN号 | 0947-6539 |
| DOI | 10.1002/chem.202402654 |
| 通讯作者 | Kang, Zheng-Hui(kangzhenghui@simm.ac.cn) ; Liu, Yun-Lin(ylliu@gzhu.edu.cn) |
| 英文摘要 | Herein a catalyst-free solvent-controlled method for the divergent synthesis of spirocyclopropyl and spiropyrazoline oxindoles from 3-ylideneoxindoles and ethyl diazoacetate was developed. With ClCH2CH2Cl as the solvent, spirocyclopropyl oxindoles were obtained in moderate to excellent yields, whereas the use of MeOH as solvent afforded spiropyrazoline oxindoles in moderate to good yields. The readily available substrates, simple operation and various product transformations further highlighted the utility of this method. |
| WOS关键词 | ENANTIOSELECTIVE 1,3-DIPOLAR CYCLOADDITIONS ; 4+1 ANNULATION REACTION ; CATALYST-FREE ; ASYMMETRIC-SYNTHESIS ; DIASTEREOSELECTIVE SYNTHESIS ; CYCLOPROPANATION ; SPIROOXINDOLES ; 3-SPIROCYCLOPROPYL-2-OXINDOLES ; YLIDENEOXINDOLES ; DIAZOOXINDOLES |
| 资助项目 | Natural Science Foundation of China ; Outstanding Youth Project of Guangdong Natural Science Foundation[2024B1515020036] ; Guangdong Natural Science Foundation[2023A1515011313] ; Guangdong Natural Science Foundation[2024A1515030037] ; Tertiary Education Scientific Research Project of Guangzhou Municipal Education Bureau[202235305] ; Natural Science Foundation of Top Talent of SZTU[GDRC202105] ; Open Fund of Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development ; [22171056] ; [21801050] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001344151700001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314315]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Kang, Zheng-Hui; Liu, Yun-Lin |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 2.East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev, Sch Chem & Mol Engn, 3663 North Zhongshan Rd, Shanghai 200062, Peoples R China 3.Guangzhou Univ, Sch Chem & Chem Engn, 230 Wai Huan Xi Rd, Guangzhou 510006, Peoples R China 4.Shenzhen Technol Univ, Coll Pharm, 3002 Lantian Rd, Shenzhen 518118, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Ding-Xiong,Huang, Yue-Mei,Lin, Xiao-Ming,et al. Solvent-Controlled Divergent Cyclization of 3-Ylideneoxindoles with Ethyl 2-Diazoacetate: Access to Spirocyclopropyl and Spiropyrazolines Oxindoles[J]. CHEMISTRY-A EUROPEAN JOURNAL,2024:7. |
| APA | Xie, Ding-Xiong.,Huang, Yue-Mei.,Lin, Xiao-Ming.,Kang, Zheng-Hui.,Ni, Chen-Chen.,...&Liu, Yun-Lin.(2024).Solvent-Controlled Divergent Cyclization of 3-Ylideneoxindoles with Ethyl 2-Diazoacetate: Access to Spirocyclopropyl and Spiropyrazolines Oxindoles.CHEMISTRY-A EUROPEAN JOURNAL,7. |
| MLA | Xie, Ding-Xiong,et al."Solvent-Controlled Divergent Cyclization of 3-Ylideneoxindoles with Ethyl 2-Diazoacetate: Access to Spirocyclopropyl and Spiropyrazolines Oxindoles".CHEMISTRY-A EUROPEAN JOURNAL (2024):7. |
入库方式： OAI收割
来源：上海药物研究所
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