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Chemoenzymatic Synthesis of Phosphosaccharides from Haemophilus parasuis Strains ER-6P (Serovar 15) and Nagasaki (Serovar 5)

文献类型：期刊论文

作者Zhu, Xinhao1,5; Yao, Wenlong2,3; Sun, Na1; Chen, Mei4; Xia, Hui1; Liu, Chang-Cheng8,9; Zhu, Yugen5; Cao, Hongzhi6,7
刊名ORGANIC LETTERS
出版日期2024-10-25
卷号26期号:44页码:9580-9585
ISSN号1523-7060
DOI10.1021/acs.orglett.4c03665
通讯作者Yao, Wenlong(yaowenlong@bjmu.edu.cn) ; Liu, Chang-Cheng(ccliu@sdu.edu.cn) ; Zhu, Yugen(zhuyugen@zidd.ac.cn) ; Cao, Hongzhi(hzcao@ouc.edu.cn)
英文摘要Herein, we describe a chemoenzymatic and diversity-oriented approach for the first syntheses of octasaccharide repeating units of the capsular polysaccharides of Haemophilus parasuis serovar 15 and serovar 5. The synthetic method features efficient enzymatic assembly of sialyl galactose or N-acetyl-galactosamine building blocks, highly stereoselective chemical construction of alpha-type H-phosphonate, and the beta-stereospecific 1,3-glycosylation reaction of a rare sugar donor.
WOS关键词LIPOTEICHOIC ACID ; ALPHA ; POLYSACCHARIDE ; LIPOPOLYSACCHARIDES ; DERIVATIVES ; INFLUENZAE ; VACCINE
资助项目Shandong University[2020258] ; Youth Innovation Promotion Association of CAS[92478131] ; Youth Innovation Promotion Association of CAS[22277066] ; Youth Innovation Promotion Association of CAS[22277111] ; National Natural Science Foundation of China[ZR2023ZD45] ; National Natural Science Foundation of China[2021ZDSYS22] ; Department of Science and Technology of Shandong Province ; Young Scholars Program of Shandong University[TSTP20221114] ; Taishan Scholar Project
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001343834700001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/314327]  
专题中国科学院上海药物研究所
通讯作者Yao, Wenlong; Liu, Chang-Cheng; Zhu, Yugen; Cao, Hongzhi
作者单位1.Shandong Univ, Natl Glycoengn Res Ctr, Qingdao 266237, Peoples R China
2.Peking Univ, Chem Biol Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
4.Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China
5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China
6.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ,Shandong Key Lab Glycoscience & Glycot, Qingdao 266003, Peoples R China
7.Qingdao Marine Sci & Technol Ctr, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China
8.Shandong Univ, Shandong Key Lab Carbohydrate Chem & Glycobiol, Qingdao 266237, Peoples R China
9.Shandong Univ, Natl Glycoengineering Res Ctr, NMPA Key Lab Qual Res & Evaluat Carbohydrate Based, Qingdao 266237, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Xinhao,Yao, Wenlong,Sun, Na,et al. Chemoenzymatic Synthesis of Phosphosaccharides from Haemophilus parasuis Strains ER-6P (Serovar 15) and Nagasaki (Serovar 5)[J]. ORGANIC LETTERS,2024,26(44):9580-9585.
APA Zhu, Xinhao.,Yao, Wenlong.,Sun, Na.,Chen, Mei.,Xia, Hui.,...&Cao, Hongzhi.(2024).Chemoenzymatic Synthesis of Phosphosaccharides from Haemophilus parasuis Strains ER-6P (Serovar 15) and Nagasaki (Serovar 5).ORGANIC LETTERS,26(44),9580-9585.
MLA Zhu, Xinhao,et al."Chemoenzymatic Synthesis of Phosphosaccharides from Haemophilus parasuis Strains ER-6P (Serovar 15) and Nagasaki (Serovar 5)".ORGANIC LETTERS 26.44(2024):9580-9585.

入库方式： OAI收割

来源：上海药物研究所

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