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Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027

文献类型：期刊论文

作者Chen, Chunmei4; Wang, Xueni3; Fang, Wenxuan2,3; Liang, Jiaqi4; Cai, Jian4; Yang, Dehua1; Luo, Xiaowei2; Gao, Chenghai2; Yi, Xiangxi2; Liu, Yonghong2,4
刊名CHINESE JOURNAL OF NATURAL MEDICINES
出版日期2024-11-01
卷号22期号:11页码:1047-1056
关键词[KEY WORDS] Mangrove sediment-derived fungus Talaromyces sp. Linear polyketides Cytotoxicity Prostate cancer.
ISSN号2095-6975
DOI10.1016/S1875-5364(24)60659-X
通讯作者Liu, Yonghong(yonghongliu@scsio.ac.cn) ; Zhou, Xuefeng(xfzhou@scsio.ac.cn)
英文摘要[ABSTRACT] Seven novel linear polyketides, talaketides A-G (1-7), were isolated from the rice media cultures of the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027. Among these, talaketides A-E (1-5) represented unprecedented unsaturated linear polyketides with an epoxy ring structure. The structures, including absolute configurations of these compounds, were elucidated through detailed analyses of nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HR-MS) data, as well as electronic custom distributors (ECD) calculations. In the cytotoxicity screening against prostate cancer cell lines, talaketide E (5) demonstrated a dose-dependent inhibitory effect on prostate cancer PC-3 cell lines, with an IC50 value of 14.44 mu molL-1 . Moreover, compound 5 significantly inhibited the cloning formation of PC-3 cell lines and arrested the cell cycle in S-phase, ultimately inducing apoptosis. These findings indicate that compound 5 may serve as a promising lead compound for the development of a potential treatment for prostate cancer. [CLC Number] R917 [Document code] A [Article ID] 2095-6975(2024)11-1047-10
WOS研究方向Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001351350000001
出版者CHINESE JOURNAL NATURAL MEDICINES
源URL[http://119.78.100.183/handle/2S10ELR8/314330]  
专题中国科学院上海药物研究所
通讯作者Liu, Yonghong; Zhou, Xuefeng
作者单位1.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Guangxi Univ Chinese Med, Inst Marine Drugs, Guangxi Key Lab Marine Drugs, Nanning 530200, Peoples R China
3.Guangxi Univ Chinese Med, Guangxi Zhuang Yao Med Ctr Engn & Technol, Nanning 530200, Peoples R China
4.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Chunmei,Wang, Xueni,Fang, Wenxuan,et al. Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2024,22(11):1047-1056.
APA Chen, Chunmei.,Wang, Xueni.,Fang, Wenxuan.,Liang, Jiaqi.,Cai, Jian.,...&Zhou, Xuefeng.(2024).Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027.CHINESE JOURNAL OF NATURAL MEDICINES,22(11),1047-1056.
MLA Chen, Chunmei,et al."Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027".CHINESE JOURNAL OF NATURAL MEDICINES 22.11(2024):1047-1056.

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来源：上海药物研究所

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