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A two-front nutrient supply environment fuels small intestinal physiology through differential regulation of nutrient absorption and host defense

文献类型：期刊论文

作者Zhang, Jian1,9,10; Tian, Ruonan7,8; Liu, Jia6; Yuan, Jie6; Zhang, Siwen5; Chi, Zhexu9,10; Yu, Weiwei9,10; Yu, Qianzhou9,10; Wang, Zhen9,10; Chen, Sheng9,10
刊名CELL
出版日期2024-10-31
卷号187期号:22页码:42
ISSN号0092-8674
DOI10.1016/j.cell.2024.08.012
通讯作者Liu, Wanlu(wanluliu@intl.zju.edu.cn) ; Wang, Di(diwang@zju.edu.cn)
英文摘要The small intestine contains a two-front nutrient supply environment created by luminal dietary and microbial metabolites (enteral side) and systemic metabolites from the host (serosal side). Yet, it is unknown how each side contributes differentially to the small intestinal physiology. Here, we generated a comprehensive, highresolution map of the small intestinal two-front nutrient supply environment. Using in vivo tracing of macro- nutrients and spatial metabolomics, we visualized the spatiotemporal dynamics and cell-type tropism in nutrient absorption and the region-specific metabolic heterogeneity within the villi. Specifically, glutamine from the enteral side fuels goblet cells to support mucus production, and the serosal side loosens the epithelial barrier by calibrating fungal metabolites. Disorganized feeding patterns, akin to the human lifestyle of skipping breakfast, increase the risk of metabolic diseases by inducing epithelial memory of lipid absorption. This study improves our understanding of how the small intestine is spatiotemporally regulated by its unique nutritional environment.
WOS关键词REDUCED MEAL FREQUENCY ; CORONARY-HEART-DISEASE ; CALORIC RESTRICTION ; NORMAL-WEIGHT ; MOUSE MODEL ; STEM-CELLS ; HEALTH ; METABOLISM ; MICROBIOME ; MUCUS
资助项目National Natural Science Foundation of China[82025017] ; National Natural Science Foundation of China[81930042] ; National Natural Science Foundation of China[32370919] ; National Natural Science Foundation of China[32100692] ; National Natural Science Foundation of China[32370832] ; China Postdoctoral Science Foundation[2023M733063] ; Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China[LHDMD23H160002] ; Key R&D Program of Zhejiang[2024SS YS0024] ; Dr. Li Dak Sum & Yip Yio Chin Development Fund for Regenerative Medicine ; Research Center of Prevention and Treatment of Senescence Syndrome, Zhejiang University School of Medicine
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
WOS记录号WOS:001349735400001
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/314342]  
专题中国科学院上海药物研究所
通讯作者Liu, Wanlu; Wang, Di
作者单位1.Zhejiang Univ, Med Ctr, Liangzhu Lab, Hangzhou 311113, Peoples R China
2.Univ Edinburgh, Coll Med & Vet Med, Biomed Sci, Edinburgh EH8 9YL, Scotland
3.Zhejiang Univ, Sch Med, Dept Pathol & Pathophysiol, Hangzhou 310058, Peoples R China
4.Univ Sci & Technol China, Sch Basic Med Sci, Key Lab Immune Response & Immunotherapy, Hefei 230027, Peoples R China
5.First Hosp Jilin Univ, Dept Endocrinol & Metab, Changchun 130061, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
7.Zhejiang Univ, Sch Med, Univ Edinburgh Inst, Ctr Biomed Syst & Informat, Hangzhou 310003, Peoples R China
8.Zhejiang Univ, Affiliated Hosp 2, Dept Rheumatol & Immunol, Hangzhou 310003, Peoples R China
9.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Hangzhou 310058, Peoples R China
10.Zhejiang Univ, Sch Med, Inst Immunol, Hangzhou 310058, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Jian,Tian, Ruonan,Liu, Jia,et al. A two-front nutrient supply environment fuels small intestinal physiology through differential regulation of nutrient absorption and host defense[J]. CELL,2024,187(22):42.
APA Zhang, Jian.,Tian, Ruonan.,Liu, Jia.,Yuan, Jie.,Zhang, Siwen.,...&Wang, Di.(2024).A two-front nutrient supply environment fuels small intestinal physiology through differential regulation of nutrient absorption and host defense.CELL,187(22),42.
MLA Zhang, Jian,et al."A two-front nutrient supply environment fuels small intestinal physiology through differential regulation of nutrient absorption and host defense".CELL 187.22(2024):42.

入库方式： OAI收割

来源：上海药物研究所

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