SIRT3 differentially regulates lysine benzoylation from SIRT2 in mammalian cells
文献类型：期刊论文
| 作者 | Peng, Panpan2,3; Lu, Ying1; Ren, Xuelian2,3; Yan, Cong2; Guo, Xinlong2; Liu, Ruilong2; Song, Xiaohan2,3; Huang, He1,2,3 |
| 刊名 | ISCIENCE
 |
| 出版日期 | 2024-11-15 |
| 卷号 | 27期号:11页码:18 |
| DOI | 10.1016/j.isci.2024.111176 |
| 通讯作者 | Huang, He(hhuang@simm.ac.cn) |
| 英文摘要 | Lysine benzoylation (Kbz), a new type of protein post-translational modification (PTM) we discovered, has garnered significant attention. While we initially identified SIRT2 as a debenzoylase in mammalian cells, recent findings suggest its exclusivity may be questioned. However, other debenzoylases in mammalian cells remain underexplored. Here, our study reveals SIRT3 as an additional debenzoylase. Through quantitative analysis, we identified 1,075 Kbz sites in mammalian cells, with 44 specifically mediated by SIRT3 and 66 influenced by SIRT2. Notably, SIRT3 and SIRT2 regulate distinct Kbz substrates, indicating involvement in different cellular processes. Functional investigations demonstrated SIRT3's regulation of benzoylated protein peptidyl-prolyl cis- trans isomerase F (PPIF), where K73bz and K197bz markedly diminished interactions with the tumor suppressor p53. Additionally, K978bz on ATP-citrate lyase (ACLY) notably inhibited its enzymatic activity. This study not only identifies a debenzoylase and its Kbz substrates but also enhances our understanding of Kbz's biological functions. |
| WOS关键词 | PERMEABILITY TRANSITION PORE ; METABOLIC-REGULATION ; GENE-EXPRESSION ; DEACETYLATION ; DEATH |
| 资助项目 | National Natural Science Foundation of China[22277125] ; National Natural Science Foundation of China[92253306] ; Natural Science Foundation of Shanghai[23ZR1474600] ; Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001347804200001 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314348]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Huang, He |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai, Peoples R China 3.Univ Chinese Acad Sci, Sch Pharmaceut Sci & Technol, Hangzhou Inst Adv Study, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Panpan,Lu, Ying,Ren, Xuelian,et al. SIRT3 differentially regulates lysine benzoylation from SIRT2 in mammalian cells[J]. ISCIENCE,2024,27(11):18. |
| APA | Peng, Panpan.,Lu, Ying.,Ren, Xuelian.,Yan, Cong.,Guo, Xinlong.,...&Huang, He.(2024).SIRT3 differentially regulates lysine benzoylation from SIRT2 in mammalian cells.ISCIENCE,27(11),18. |
| MLA | Peng, Panpan,et al."SIRT3 differentially regulates lysine benzoylation from SIRT2 in mammalian cells".ISCIENCE 27.11(2024):18. |
入库方式： OAI收割
来源：上海药物研究所
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