The biologically and ecologically important natural products from the Chinese sea hare Bursatella leachii: structures, stereochemistry and beyond
文献类型：期刊论文
| 作者 | Zhang, Xinyuan1,2,3; Su, Mingzhi3; Zhu, Mingxin2,3; Chen, Sha3; Gao, Zhen3; Guo, Yuewei1,2,3 ; Li, Xuwen1,2,3
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| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
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| 出版日期 | 2024-11-01 |
| 卷号 | 22期号:11页码:1030-1039 |
| 关键词 | Bursatella leachii Marine natural product Alkaloid Sea hare Antibacterial activity |
| ISSN号 | 2095-6975 |
| DOI | 10.1016/S1875-5364(24)60611-4 |
| 通讯作者 | Guo, Yuewei(ywguo@simm.ac.cn) ; Li, Xuwen(xwli@simm.ac.cn) |
| 英文摘要 | A novel amide alkaloid, bursatamide A (1), featuring an unprecedented propyl-hexahydronaphthalene carbon framework, was isolated from the infrequently studied sea hare Bursatella leachi, alongside a new 3-phenoxypropanenitrile alkaloid, bursatellin B (2), and twelve known compounds. The structures of 1 and 2 were elucidated through comprehensive spectroscopic data analyses, while their relative and absolute configurations (ACs) were established through total synthesis and a series of quantum chemical calculations, including calculated electronic circular dichroism (ECD) spectra, optical rotatory dispersion (ORD) methods, and DP4+ probability analyses. Bursatamide A (1) demonstrated inhibitory effects against the human pathogenic bacteria Listeria monocytogenes and Vibrio cholerae. Erythro-bursatellin B (21), a diastereoisomer of 2 , exhibited notable antibacterial activity against the fish pathogenic bacterium Streptococcus parauberis FP KSP28, with an MIC90 value of 0.0472 mu g |
| 资助项目 | National Key Research and Development Program of China[2021YFF0502400] ; National Key Research and Development Program of China[2022YFC2804100] ; Natural Science Foundation of China[82022069] ; Natural Science Foundation of China[42076099] ; Shandong Laboratory Program[SYS202205] ; Youth Innovation Promotion Association of CAS[Y202065] ; Fundamental Research Projects of Science & Technology In-novation and development Plan in Yantai City[2023JCYJ057] ; CAS Youth Interdisciplinary Team ; Shandong Science and Technology Major Project of Innovation and Entrepreneurship Community[E321020] ; Youth Fund from Natural Science Foundation of Shandong Province[ZR2023QD162] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001351593600001 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314357]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, Yuewei; Li, Xuwen |
| 作者单位 | 1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 3.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xinyuan,Su, Mingzhi,Zhu, Mingxin,et al. The biologically and ecologically important natural products from the Chinese sea hare Bursatella leachii: structures, stereochemistry and beyond[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2024,22(11):1030-1039. |
| APA | Zhang, Xinyuan.,Su, Mingzhi.,Zhu, Mingxin.,Chen, Sha.,Gao, Zhen.,...&Li, Xuwen.(2024).The biologically and ecologically important natural products from the Chinese sea hare Bursatella leachii: structures, stereochemistry and beyond.CHINESE JOURNAL OF NATURAL MEDICINES,22(11),1030-1039. |
| MLA | Zhang, Xinyuan,et al."The biologically and ecologically important natural products from the Chinese sea hare Bursatella leachii: structures, stereochemistry and beyond".CHINESE JOURNAL OF NATURAL MEDICINES 22.11(2024):1030-1039. |
入库方式： OAI收割
来源：上海药物研究所
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