Supramolecular cyclodextrin-based reservoir as nasal delivery vehicle for rivastigmine to brain
文献类型：期刊论文
| 作者 | Wang, Manli1,2; Lv, Yuting2,4; Xu, Huipeng5; Zhao, Xiangyu2,4; Zhang, Guoqing2; Wang, Siwen5; Wang, Caifen3,5; Wu, Wenting1; Wu, Li1,5; Zhu, Weifeng1 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2025-01-15 |
| 卷号 | 348页码:14 |
| 关键词 | Supramolecular reservoir Intranasal administration Rivastigmine Cyclodextrin metal-organic framework Borneol Brain targeting |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2024.122881 |
| 通讯作者 | Wu, Li(wuli@simm.ac.cn) ; Zhu, Weifeng(19930220@jxutcm.edu.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | The purpose of this study involved the synthesis of supramolecular reservoir (i.e. cyclodextrin metal-organic framework, MOF) using cyclodextrins as building blocks, followed by cross-linking to obtain crosslinked CD framework (CDF) using CD-MOF as template and functionalized with borneol (BO) to enhance rivastigmine (RIV) permeation and facilitate brain targeting via intranasal administration. Utilizing BO modified CDF (BO-CDF) with cubic shape as a carrier for the encapsulation of RIV, a nasal RIV delivery system (RIV@BO-CDF) was fabricated. The particle size of RIV@BO-CDF was approximately 250 nm, and the drug loading capacity reached 15 +/- 2 %. BO-CDF improved the mucoadhesion and enhanced RIV permeability with the plasma concentration- time curve (AUC), the brain AUC and the peak drug concentration within brain in rats 1.7, 2.3 and 8 times than that of oral RIV solution, respectively. The relative drug targeting efficiency percentage (DTE, 139.4 %) and direct drug transfer percentage (DTP, 28.3 %) of RIV@BO-COF indicated good targeting efficiency and direct nose-to-brain drug delivery. Overall, this study provides a potential application of supramolecular cyclodextrinbased reservoir to enhance the brain targeting and efficacy of the RIV via nasal delivery. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; NANOPARTICLES ; NOSE ; BIOAVAILABILITY ; PERMEABILITY ; ENHANCEMENT ; INHIBITION ; CHITOSAN ; BARRIER ; BORNEOL |
| 资助项目 | Central Guidance for Local Scientific and Technological Development Funding Projects[20222ZDH01096] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001349275600001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314360]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, Li; Zhu, Weifeng; Zhang, Jiwen |
| 作者单位 | 1.Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China 2.Jiangsu Yungou Pharmaceut Technol Co Ltd, Nantong 226133, Peoples R China 3.Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China 4.Anhui Univ Chinese Med, Hefei 230000, Anhui, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Manli,Lv, Yuting,Xu, Huipeng,et al. Supramolecular cyclodextrin-based reservoir as nasal delivery vehicle for rivastigmine to brain[J]. CARBOHYDRATE POLYMERS,2025,348:14. |
| APA | Wang, Manli.,Lv, Yuting.,Xu, Huipeng.,Zhao, Xiangyu.,Zhang, Guoqing.,...&Zhang, Jiwen.(2025).Supramolecular cyclodextrin-based reservoir as nasal delivery vehicle for rivastigmine to brain.CARBOHYDRATE POLYMERS,348,14. |
| MLA | Wang, Manli,et al."Supramolecular cyclodextrin-based reservoir as nasal delivery vehicle for rivastigmine to brain".CARBOHYDRATE POLYMERS 348(2025):14. |
入库方式： OAI收割
来源：上海药物研究所
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