NIR-II fluorescence lateral flow immunosensor based on efficient energy transfer probe for point-of-care testing of tumor biomarkers
文献类型：期刊论文
| 作者 | Song, Zhaorui2; Hao, Qiulian2; Li, Bing4; Yuan, Yuwei1; Zhang, Shanshan2; Suo, Yongkuan2,3,5; Han, Hai-Hao1,2,3,5; Cheng, Zhen2,3,4,5 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2025 |
| 卷号 | 36期号:1页码:5 |
| 关键词 | Donor-acceptor energy transfer (ET) Lateral flow immunoassay (LFA) The second near-infrared (NIR-II) fluorescence Rare-earth nanoparticles (RENPs) Poly(lactic acid co -glycolic acid) (PLGA) Tumor biomarker |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2024.109834 |
| 通讯作者 | Suo, Yongkuan(suoyongkuan@simm.ac.cn) ; Han, Hai-Hao(hanhaihao@simm.ac.cn) ; Cheng, Zhen(zcheng@simm.ac.cn) |
| 英文摘要 | Fluorescence lateral flow immunoassay (LFA) has emerged as a powerful tool for rapid screening of various biomarkers owing to its simplicity, sensitivity and flexibility. It is noteworthy that fluorescent probe mainly determines the analytical performance of LFA. Due to the emission and excitation wavelengths are located in the visible region, most fluorophores are inevitably subject to light scattering and background autofluorescence. Herein, we reported a novel LFA sensor based on the second near-infrared (NIR-II) fluorescent probe with excellent anti-interference capability. The designed NIR-II probe was the Nd3 + and Yb3 + doped rare earth nanoparticles (RENPs) by employing Nd3 + as energy donor and Yb3 + as energy acceptor, which of the donor-acceptor energy transfer (ET) efficiency reached up to 80.7 %. Meanwhile, relying on the convenient and effective encapsulation strategy of poly(lactic- co -glycolic acid) (PLGA) microspheres to RENPs, the surface functionalized NIR-II probe (RE@PLGA) was obtained for subsequent bioconjugation. Benefiting from the optical advantages of NIR-II probe, this proposed NIR-II LFA displayed a good linear relationship ranging from 7 ng/mL to 200 ng/mL for the detection of alpha-fetoprotein (AFP), an important biomarker of hepatocellular carcinoma (HCC). The limit of detection (LOD) was determined as low as 3.0 ng/mL, which was of 8.3 times lower than clinical cutoff value. It is promising that LFA sensor based on this efficient RENPs probe provides new opportunities for high sensitive detection of various biomarkers in biological samples. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
| WOS关键词 | UP-CONVERSION ; FLUORIDE ; DYE |
| 资助项目 | National Natural Science Foundation of China[U2267221] ; National Natural Science Foundation of China[22107029] ; National Natural Science Foundation of China[22377135] ; Bohai Rim Advanced Research Institute for Drug Discovery[LX215002] ; Natural Science Foundation of Shandong Province[ZR2022QH212] ; Taishan Scholars Program[tsqn202312305] ; Young Elite Scientists Sponsorship Pro-gram by Chinese Chemical Society ; Fundamental Research Projects of Science & Technology Innovation and development Plan in Yantai City[2023JCYJ059] ; Shandong Laboratory Program[SYS202205] ; Shanghai Postdoctoral Excellence Program[2023704] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001349981000001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314367]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Suo, Yongkuan; Han, Hai-Hao; Cheng, Zhen |
| 作者单位 | 1.Shandong First Med Univ & Shandong Acad Med Sci, Pharm Coll, Jinan 250117, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 3.Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Northeastern Univ, Inst Mol Med Joint Lab Mol Med, Shenyang 110000, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Zhaorui,Hao, Qiulian,Li, Bing,et al. NIR-II fluorescence lateral flow immunosensor based on efficient energy transfer probe for point-of-care testing of tumor biomarkers[J]. CHINESE CHEMICAL LETTERS,2025,36(1):5. |
| APA | Song, Zhaorui.,Hao, Qiulian.,Li, Bing.,Yuan, Yuwei.,Zhang, Shanshan.,...&Cheng, Zhen.(2025).NIR-II fluorescence lateral flow immunosensor based on efficient energy transfer probe for point-of-care testing of tumor biomarkers.CHINESE CHEMICAL LETTERS,36(1),5. |
| MLA | Song, Zhaorui,et al."NIR-II fluorescence lateral flow immunosensor based on efficient energy transfer probe for point-of-care testing of tumor biomarkers".CHINESE CHEMICAL LETTERS 36.1(2025):5. |
入库方式： OAI收割
来源：上海药物研究所
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