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Non-natural sialic acid derivatives with o-nitrobenzyl alcohol substituents for light-mediated protein conjugation and cell imaging

文献类型：期刊论文

作者Zhu, Guo-Biao2,3; Guo, Chen2,3; Ren, Xue-Lian1,8; Li, Ming-Zhe5; Lu, Di-Ya5; Hu, Xi-Le2,3; Huang, He1,8; James, Tony D.6,7; He, Xiao-Peng2,3,4,5
刊名ORGANIC & BIOMOLECULAR CHEMISTRY
出版日期2024-11-04
页码5
ISSN号1477-0520
DOI10.1039/d4ob01563k
通讯作者Hu, Xi-Le(xlhu@ecust.edu.cn) ; Huang, He(hhuang@simm.ac.cn) ; James, Tony D.(t.d.james@bath.ac.uk) ; He, Xiao-Peng(xphe@ecust.edu.cn)
英文摘要We have synthesized two sialic acid derivatives substituted with an ortho-nitrobenzyl alcohol (o-NBA) group that can undergo light-mediated conjugation with primary amines at their 5- or 9-carbon position. The o-NBA derivatives were shown to react with multiple lysine residues of human serum albumin (HSA) when exposed to 365 nm light irradiation within 10 min. The resulting sugar conjugates were characterized by mass spectroscopy and used for fluorescence-based cell imaging.
WOS关键词CAPTURE ; PROBES
资助项目National Natural Science Foundation of China[92253306] ; National Natural Science Foundation of China[82130099] ; National Natural Science Foundation of China[22108077] ; Natural National Science Foundation of China (NSFC)[2018SHZDZX03] ; Shanghai Municipal Science and Technology Major Project[23490711600] ; International Cooperation Program of Shanghai Science and Technology[222201717003] ; Fundamental Research Funds for the Central Universities[B16017] ; Programme of Introducing Talents of Discipline to Universities[SKLDR-2023-KF-10] ; Open Funding Project of the State Key Laboratory of Bioreactor Engineering, State Key Laboratory of Drug Research[2023-MEKLLC-MS/ZD-00*] ; Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer (Naval Medical University) ; University of Bath[2020ZD01] ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University ; Research Center of Analysis and Test of East China University of Science and Technology
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001348626900001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/314373]  
专题中国科学院上海药物研究所
通讯作者Hu, Xi-Le; Huang, He; James, Tony D.; He, Xiao-Peng
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
2.East China Univ Sci & Technol, Key Lab Adv Mat, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem,Sch Chem &, 130 Meilong RD, Shanghai 200237, Peoples R China
3.East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem,Sch Chem &, 130 Meilong RD, Shanghai 200237, Peoples R China
4.Eastern Hepatobiliary Surg Hosp, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Shanghai 200438, Peoples R China
5.Shanghai World Foreign Language Acad, 400 Baihua St, Shanghai 200233, Peoples R China
6.Univ Bath, Dept Chem, Bath BA2 7AY, England
7.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China
8.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Guo-Biao,Guo, Chen,Ren, Xue-Lian,et al. Non-natural sialic acid derivatives with o-nitrobenzyl alcohol substituents for light-mediated protein conjugation and cell imaging[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2024:5.
APA Zhu, Guo-Biao.,Guo, Chen.,Ren, Xue-Lian.,Li, Ming-Zhe.,Lu, Di-Ya.,...&He, Xiao-Peng.(2024).Non-natural sialic acid derivatives with o-nitrobenzyl alcohol substituents for light-mediated protein conjugation and cell imaging.ORGANIC & BIOMOLECULAR CHEMISTRY,5.
MLA Zhu, Guo-Biao,et al."Non-natural sialic acid derivatives with o-nitrobenzyl alcohol substituents for light-mediated protein conjugation and cell imaging".ORGANIC & BIOMOLECULAR CHEMISTRY (2024):5.

入库方式： OAI收割

来源：上海药物研究所

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