Amino acid is a major carbon source for hepatic lipogenesis
文献类型：期刊论文
| 作者 | Liao, Yilie4,6,8; Chen, Qishan7; Liu, Lei6; Huang, Haipeng1,6; Sun, Jingyun5; Bai, Xiaojie6; Jin, Chenchen7; Li, Honghao6; Sun, Fangfang6; Xiao, Xia6 |
| 刊名 | CELL METABOLISM
 |
| 出版日期 | 2024-11-05 |
| 卷号 | 36期号:11页码:21 |
| ISSN号 | 1550-4131 |
| DOI | 10.1016/j.cmet.2024.10.001 |
| 通讯作者 | Liao, Yilie(liaoyilie329@zidd.ac.cn) ; Han, Weiping(wh10@cornell.edu) ; Fu, Suneng(fu_suneng@gzlab.ac.cn) |
| 英文摘要 | Increased de novo lipogenesis is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD) in obesity, but the macronutrient carbon source for over half of hepatic fatty acid synthesis remains undetermined. Here, we discover that dietary protein, rather than carbohydrates or fat, is the primary nutritional risk factor for MASLD in humans. Consistently, ex vivo tracing studies identify amino acids as a major carbon supplier for the tricarboxylic acid (TCA) cycle and lipogenesis in isolated mouse hepatocytes. In vivo, dietary amino acids are twice as efficient as glucose in fueling hepatic fatty acid synthesis. The onset of obesity further drives amino acids into fatty acid synthesis through reductive carboxylation, while genetic and chemical interventions that divert amino acid carbon away from lipogenesis alleviate hepatic steatosis. Finally, low-protein diets (LPDs) not only prevent body weight gain in obese mice but also reduce hepatic lipid accumulation and liver damage. Together, this study uncovers the significant role of amino acids in hepatic lipogenesis and suggests a previously unappreciated nutritional intervention target for MASLD. |
| WOS关键词 | DE-NOVO LIPOGENESIS ; IN-VIVO ; HIGH-PROTEIN ; GLUCOSE ; MODEL ; RATES ; FLUX |
| 资助项目 | National Science and Technology Major Project[2016YFA0502002] ; National Natural Science Foundation of China[81471072] ; National Natural Science Foundation of China[31671229] ; Guangzhou National Laboratory[YW-JCYJ0404] ; Guangzhou National Laboratory[MP-GZNL2023A02004-2] ; Agency for Science, Technology, and Research (A*STAR) Biomedical Research Council core fund ; A*STAR Strategic Research Program[21718] ; A*STAR Use-Inspired Basic Research Award ; National Research Foundation Competitive Research Program (CRP)[NRF-CRP23-2019-0004] ; Zhongshan Institute for Drug Discovery (ZIDD) ; Human Resources and Social Security Bureau of Guangzhou City and Huangpu District ; Zhongshan Institute for Drug Discovery grant[ZIDD202301] |
| WOS研究方向 | Cell Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:001352910500001 |
| 出版者 | CELL PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314382]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liao, Yilie; Han, Weiping; Fu, Suneng |
| 作者单位 | 1.Peking Univ, Inst Mol Med, Coll Future Technol, Beijing 100871, Peoples R China 2.ASTAR, Inst Mol & Cell Biol, Proteos, 61 Biopolis Dr, Singapore 138673, Singapore 3.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, Shanghai 201203, Peoples R China 4.Natl Univ Singapore, Duke NUS Med Sch, Singapore 169857, Singapore 5.Ctr Neurometab & Regenerat Med, Bioland Labs, Guangzhou 510530, Guangdong, Peoples R China 6.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China 7.Guangzhou Natl Lab, Guangzhou 510005, Guangdong, Peoples R China 8.Chinese Acad Sci, Zhongshan Inst Drug Discovery ZIDD, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao, Yilie,Chen, Qishan,Liu, Lei,et al. Amino acid is a major carbon source for hepatic lipogenesis[J]. CELL METABOLISM,2024,36(11):21. |
| APA | Liao, Yilie.,Chen, Qishan.,Liu, Lei.,Huang, Haipeng.,Sun, Jingyun.,...&Fu, Suneng.(2024).Amino acid is a major carbon source for hepatic lipogenesis.CELL METABOLISM,36(11),21. |
| MLA | Liao, Yilie,et al."Amino acid is a major carbon source for hepatic lipogenesis".CELL METABOLISM 36.11(2024):21. |
入库方式： OAI收割
来源：上海药物研究所
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