Cryo-EM structure of human HCN3 channel and its regulation by cAMP
文献类型：期刊论文
| 作者 | Yu, Bo2,3; Lu, Qiuyuan4; Li, Jian5; Cheng, Xinyu3; Hu, Han6; Li, Yuanshuo6; Che, Tong2,3; Hua, Yaoguang2,3; Jiang, Haihai2,3; Zhang, Yuting6 |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
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| 出版日期 | 2024-06-01 |
| 卷号 | 300期号:6页码:10 |
| DOI | 10.1016/j.jbc.2024.107288 |
| 通讯作者 | Li, Yanyan(liyy6@sustech.edu.cn) ; Fu, Yang(fuy@sustech.edu.cn) ; Zhang, Jin(zhangxiaokong@hotmail.com) |
| 英文摘要 | HCN channels are important for regulating heart rhythm and nerve activity and have been studied as potential drug targets for treating depression, arrhythmia, nerve pain, and ties, HCN channels share common characteristics in that they are activated by hyperpolarization and modulated by cAMP and other membrane lipids. However, the mechanisms of how these ligands bind and modulate HCN channels are unclear. In this study, we solved structures of full-length human HCN3 using cryo-EM and captured two different states, including a state without any ligand bound and a state with cAMP bound. tive treatment. |
| WOS关键词 | ACTIVATED CATION CHANNEL ; PACEMAKER CHANNELS ; BINDING DOMAIN ; ION CHANNELS ; K+ CHANNEL ; HYPERPOLARIZATION ; EXPRESSION ; MOVEMENTS ; DYNAMICS ; LIGAND |
| 资助项目 | National Natural Science Foundation of China[32322004] ; National Natural Science Foundation of China[32171205] ; National Natural Science Foundation of China[U22A20338] ; Jiangxi Province Natural Science Foundation[20224ACB206046] ; Open Project of Key Laboratory of Prevention and treatment of cardiovascular and cerebrovascular diseases, Ministry of Education[XN201904] ; Gannan Medical University[QD201910] ; Jiangxi Key Research and Development Program[20203BBG73063] ; Jiangxi Double Thousand Plan ; Foreign Talent project of Jiangxi Province ; Shenzhen Science and Technology Program[JCYJ20210324115611032] ; Shenzhen Science and Technology Program[KQTD20200909113758004] ; Ganzhou COVID-19 Emergency Research Project[2020.17] ; Major science and technology programs of Ganzhou City[2020.67] ; Ganzhou Zhanggong District COVID-19 prevention and control key research projects[2020.67] ; Shenzhen Natural Science Founda-tion[20220815130429001] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001345382500001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314391]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yanyan; Fu, Yang; Zhang, Jin |
| 作者单位 | 1.Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, London, England 2.Hubei Univ Sci & Technol, Sch Basic Med Sci, Res Ctr Basic Med Sci, Xianning 437100, Peoples R China 3.Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Neurosurg, Nanchang 330006, Jiangxi, Peoples R China 4.Southern Univ Sci & Technol, Sch Med, Shenzhen, Guangdong, Peoples R China 5.Gannan Med Univ, Coll Pharm, Ganzhou, Peoples R China 6.Shenzhen Crystalo Biopharmaceut Co Ltd, Shenzhen 518118, Guangdong, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China 8.Nanchang Univ, Human Aging Res Inst HARI, Sch Life Sci, Canc & Cell Senescence, Nanchang, Jiangxi, Peoples R China 9.Southwest Med Univ, Inst Cardiovasc Res, Med Electrophysiol Key Lab Sichuan Prov, Key Lab Med Electrophysiol,Minist Educ, Luzhou, Sichuan, Peoples R China 10.Southern Univ Sci & Technol, Sch Life Sci, Dept Chem Biol, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Bo,Lu, Qiuyuan,Li, Jian,et al. Cryo-EM structure of human HCN3 channel and its regulation by cAMP[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2024,300(6):10. |
| APA | Yu, Bo.,Lu, Qiuyuan.,Li, Jian.,Cheng, Xinyu.,Hu, Han.,...&Zhang, Jin.(2024).Cryo-EM structure of human HCN3 channel and its regulation by cAMP.JOURNAL OF BIOLOGICAL CHEMISTRY,300(6),10. |
| MLA | Yu, Bo,et al."Cryo-EM structure of human HCN3 channel and its regulation by cAMP".JOURNAL OF BIOLOGICAL CHEMISTRY 300.6(2024):10. |
入库方式： OAI收割
来源：上海药物研究所
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