Polymethoxylated flavones for modulating signaling pathways in inflammation
文献类型：期刊论文
| 作者 | Yue, Lixia1,5; Li, Ning4; Ye, Xianglu3; Xiu, Yanfeng1; Wang, Bing2 |
| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2024-12-25 |
| 卷号 | 143页码:11 |
| 关键词 | Polymethoxylated flavones Signaling pathways Therapeutics mechanisms Inflammatory diseases |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2024.113522 |
| 通讯作者 | Xiu, Yanfeng(xiuyanfeng@shutcm.edu.cn) ; Wang, Bing(bwang@shsci.org) |
| 英文摘要 | Aberrant signaling pathways play a crucial role in the pathogenesis of various diseases, including inflammatory disorders and autoimmune conditions. Polymethoxylated flavones (PMFs), a class of natural compounds found in citrus fruits, have obtained increasing attention for their potential therapeutic effects in modulating inflammatory responses. Although significant progress has been made in the pharmacological research of PMFs, the mechanisms by which they modulate signaling pathways to treat inflammation have not been systematically reviewed or analyzed. To address this gap in the literature, this review explores the mechanisms underlying the anti-inflammatory properties of PMFs and their prospects as drugs for treating inflammatory diseases. We discuss the molecular targets and signaling pathways through which PMFs exert their anti-inflammatory effects, including NF-kappa B pathway, PI3K/Akt pathway, MAPK pathway, Nrf2 pathway, and regulation of inflammatory cytokine production. Furthermore, we highlight preclinical studies evaluating the efficacy of PMFs in various inflammatory conditions, such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and osteoarthritis (OA). Despite promising findings, challenges remain in optimizing the pharmacokinetic properties and therapeutic efficacy of PMFs for clinical use. Future research directions include elucidating the structure-activity relationships of PMFs, developing novel delivery strategies, and conducting large-scale clinical trials to validate their efficacy and safety profiles. Overall, PMFs represent a promising class of natural compounds with potential applications as anti-inflammatory drugs, offering novel therapeutic opportunities for managing inflammatory diseases. |
| WOS关键词 | NF-KAPPA-B ; ACTIVATED PROTEIN-KINASE ; ULCERATIVE-COLITIS ; RHEUMATOID-ARTHRITIS ; SYNOVIAL FIBROBLASTS ; INHIBITS APOPTOSIS ; KEAP1-NRF2 PATHWAY ; HUMAN CHONDROCYTES ; DOWN-REGULATION ; IN-VIVO |
| 资助项目 | Program of the Shanghai Committee of Science and Technology, China[22S21902900] |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001354687100001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314406]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xiu, Yanfeng; Wang, Bing |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Canc Inst, Sch Med, Shanghai, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China 4.Hong Kong Univ Sci & Technol, Shenzhen Res Inst, Shenzhen 518054, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yue, Lixia,Li, Ning,Ye, Xianglu,et al. Polymethoxylated flavones for modulating signaling pathways in inflammation[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2024,143:11. |
| APA | Yue, Lixia,Li, Ning,Ye, Xianglu,Xiu, Yanfeng,&Wang, Bing.(2024).Polymethoxylated flavones for modulating signaling pathways in inflammation.INTERNATIONAL IMMUNOPHARMACOLOGY,143,11. |
| MLA | Yue, Lixia,et al."Polymethoxylated flavones for modulating signaling pathways in inflammation".INTERNATIONAL IMMUNOPHARMACOLOGY 143(2024):11. |
入库方式： OAI收割
来源：上海药物研究所
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