Method development and application for multi-phenolic components in the processing of Dendrobium officinale using UPLC coupled with mass spectrometry and chemometric analysis
文献类型：期刊论文
| 作者 | Yang, Xinxin1; Liu, Pengfei1,2; Wang, Fengzhong1; Zhang, Tingting1; Li, Nengbo3; Lu, Cong1; Tong, Litao1; Liu, Jiameng1; Sun, Jing1; Fan, Bei1 |
| 刊名 | INDUSTRIAL CROPS AND PRODUCTS
 |
| 出版日期 | 2024-12-15 |
| 卷号 | 222页码:11 |
| 关键词 | Dendrobium officinale chemometrics UPLC-MS/MS alpha-glucosidase inhibition |
| ISSN号 | 0926-6690 |
| DOI | 10.1016/j.indcrop.2024.120009 |
| 通讯作者 | Sun, Jing(ycsunjing2008@126.com) ; Fan, Bei(fanbei517@163.com) |
| 英文摘要 | Dendrobium officinale (DO) is a perennial herb that has been utilized medicinal and edible purposes for thousands of years, often transforming into 'Fengdou' after drying. Despite its long-standing use, the specific phenolic components present during DO processing have remained elusive. This study established a method for the simultaneous and accurate quantification of 27 phenolic compounds during DO processing employing ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), with 8 reference-free components optimized through an online strategy. Furthermore, correlation analysis and molecular docking were conducted to further screened and validated 6 phenolics with alpha-glucosidase inhibitory activity, including vanillin, p-coumaric acid, 4-hydroxybenzaldehyde, resveratrol, coniferyl alcohol, and dihydropinosylvin. Notably, resveratrol exhibited the lowest binding energy at -7.7 kcal/mol among these compounds. These findings significantly contribute to the development of the deep-processing techniques for DO and the hypoglycaemic functional food industry by providing data that support the elucidation of medicinal substances in DO. |
| WOS关键词 | ANTIOXIDANT ACTIVITY ; PEUCEDANI RADIX ; HUMAN PLASMA ; POLYSACCHARIDES |
| 资助项目 | Key R and D Program of Xinjiang[2022B02037-4] ; National Key R and D Program of China[2022YFD1600303] ; National Key R and D Program of China[2022YFC2010104] ; National Natural Science Foundation of China[32101957] ; Agricultural Science and Tech-nology Innovation Program of Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences[CAAS-ASTIP-G2022-IFST04] ; Agricultural Science and Tech-nology Innovation Program of Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences[CAAS-ASTIP-G2022-IFST-08] ; Science and Technology Major Project of Yunnan |
| WOS研究方向 | Agriculture |
| 语种 | 英语 |
| WOS记录号 | WOS:001356148200001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/314424]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Sun, Jing; Fan, Bei |
| 作者单位 | 1.Chinese Acad Agr Sci, Inst Food Sci & Technol, Key Lab Agroprod Proc, Minist Agr & Rural Affairs, Beijing 100193, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China 3.Inst Caulis Dendrobii Longling Cty, Baoshan 678300, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xinxin,Liu, Pengfei,Wang, Fengzhong,et al. Method development and application for multi-phenolic components in the processing of Dendrobium officinale using UPLC coupled with mass spectrometry and chemometric analysis[J]. INDUSTRIAL CROPS AND PRODUCTS,2024,222:11. |
| APA | Yang, Xinxin.,Liu, Pengfei.,Wang, Fengzhong.,Zhang, Tingting.,Li, Nengbo.,...&Fan, Bei.(2024).Method development and application for multi-phenolic components in the processing of Dendrobium officinale using UPLC coupled with mass spectrometry and chemometric analysis.INDUSTRIAL CROPS AND PRODUCTS,222,11. |
| MLA | Yang, Xinxin,et al."Method development and application for multi-phenolic components in the processing of Dendrobium officinale using UPLC coupled with mass spectrometry and chemometric analysis".INDUSTRIAL CROPS AND PRODUCTS 222(2024):11. |
入库方式： OAI收割
来源：上海药物研究所
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